Drilldown: Medicines

Etodolac (1) · Nabumetone (1)

Lodine (US brand discontinued); generic (1) · Relafen (1)

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'"`UNIQ--vote-000011F4-QINU`"' Like all NSAIDs, raises CV thrombotic risk modestly (FDA 2014/2015 advisory) and produces GI, renal, hypertensive, and platelet-inhibitory effects characteristic of the class'"`UNIQ--ref-000011F5-QINU`"'. (1) · '"`UNIQ--vote-00001269-QINU`"' Renal, GI, hypertensive, and CV effects parallel the class profile; modest COX-2 preference may underlie some literature suggesting slightly better GI tolerability than non-selective NSAIDs, though clinically the difference is small'"`UNIQ--ref-0000126A-QINU`"'. (1)

'"`UNIQ--vote-000011F6-QINU`"', '"`UNIQ--vote-000011F7-QINU`"', '"`UNIQ--vote-000011F8-QINU`"' (1) · '"`UNIQ--vote-0000126B-QINU`"', '"`UNIQ--vote-0000126C-QINU`"', '"`UNIQ--vote-0000126D-QINU`"' (1)

1000 mg PO once daily; 500-2000 mg/d in single or divided doses (1) · IR 200-400 mg PO every 6-8 hours; ER 400-1000 mg PO once daily (1)

200, 300, 400, 500 mg IR tablets/capsules; 400, 500, 600 mg ER tablets (1) · 500, 750 mg tablets (1)

1000 mg/d (osteoarthritis); 1200 mg/d (rheumatoid arthritis) (1) · 2000 mg/d (1)

Oral (2)

Analgesia within 30 minutes; full anti-inflammatory effect over days (1) · Analgesia within hours; anti-inflammatory effect over days (1)

24 hours (1) · 6-8 hours (IR); 24 hours (ER) (1)

~24 hours (6-methoxy-2-naphthylacetic acid, the active metabolite)'"`UNIQ--ref-000011F9-QINU`"' (1) · ~7 hours'"`UNIQ--ref-0000126E-QINU`"' (1)

~100% (oral; absorption complete)'"`UNIQ--ref-0000126F-QINU`"' (1) · ~38% (oral; non-acidic prodrug improves GI tolerability over many other NSAIDs)'"`UNIQ--ref-000011FA-QINU`"' (1)

Avoid after 20 weeks (NSAID-class FDA 2020 advisory on fetal renal injury and oligohydramnios with second/third-trimester use).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Avoid after 20 weeks (NSAID-class FDA 2020 advisory).<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)

[[USLegal:Prescription only|Rx-only]] in US. Carries the NSAID-class '''Boxed Warning''' for cardiovascular thrombotic events and serious GI bleeding'"`UNIQ--ref-000011FB-QINU`"' (1) · [[USLegal:Prescription only|Rx-only]] in US. NSAID-class '''Boxed Warning''' for CV thrombotic events and GI bleeding'"`UNIQ--ref-00001270-QINU`"' (1)