Tamsulosin
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Tamsulosin
Flomax
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Pharmacy
Starting dose
0.4 mg PO once daily, 30 minutes after the same meal each day
Preparations
0.4 mg capsules
US FDA Max
0.8 mg/d (rarely needed)
Pharmacology
Routes
Oral
Onset
Symptom improvement within 1 week; peak effect at 4-6 weeks
Duration
24 hours
Half-life
9-15 hours[1]
Bioavailability
>90% (oral; food slows absorption and reduces peaks, hence the post-meal dosing rule)[1]
Pregnancy
Not applicable (male indication); historical Category B if used in unrelated female cases.[citation needed]
Legal status
Rx-only in US
Purported mechanism
Tamsulosin selectively antagonizes α1A adrenergic receptors, the dominant subtype in prostatic and bladder-neck smooth muscle, relaxing outflow tract tone and improving urodynamic flow with less peripheral hypotension than non-selective α-blockers.0 CYP3A4 and CYP2D6 substrate. The α1A-selective binding underlies intraoperative floppy iris syndrome (IFIS), a recognized cataract-surgery complication that does not reverse after stopping the drug; preoperative disclosure is standard[1].
References
- ↑ 1.0 1.1 1.2 FDA Prescribing Information, Flomax (tamsulosin HCl), Boehringer Ingelheim, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020579s044lbl.pdf