Nebivolol: Difference between revisions

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| legal = Rx-only in US

| mechanism = The d-enantiomer is a highly β1-selective antagonist; the l-enantiomer triggers endothelial nitric-oxide–mediated vasodilation. Unique among beta blockers for this NO mechanism.

| intro = Nebivolol is a third-generation beta blocker with two stereoisomers: d-nebivolol provides highly β1-selective blockade, while l-nebivolol releases endothelial NO and produces direct vasodilation. The result is a favorable side-effect profile relative to older beta blockers — less fatigue, less sexual dysfunction, and even some evidence of improved erectile function. FDA-approved only for hypertension in the US.

| intro = Nebivolol is a third-generation beta blocker with two stereoisomers: d-nebivolol provides highly β1-selective blockade, while l-nebivolol releases endothelial NO and produces direct vasodilation. The result is a favorable side-effect profile relative to older beta blockers, less fatigue, less sexual dysfunction, and even some evidence of improved erectile function. FDA-approved only for hypertension in the US.

| indications =

| dosing =

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| pregnancy_details =

| monitoring = Heart rate, blood pressure

| counseling = Do not stop abruptly. Tolerated well by many patients who can't tolerate other beta blockers, but the FDA ~~indication~~ is HTN only — off-label use in HF lacks the trial evidence of metoprolol succinate / bisoprolol / carvedilol.

| counseling = Do not stop abruptly. Tolerated well by many patients who can't tolerate other beta blockers, but the FDA problem is HTN only, off-label use in HF lacks the trial evidence of metoprolol succinate / bisoprolol / carvedilol.

| anecdotes =

| seealso = [[Metoprolol]], [[Bisoprolol]], [[Propranolol]]

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