Tadalafil: Difference between revisions
| [unchecked revision] | [unchecked revision] |
MDElliottMD (talk | contribs) Create Tadalafil scaffold |
MDElliottMD (talk | contribs) Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved. |
||
| Line 27: | Line 27: | ||
| pregnancy_details = | | pregnancy_details = | ||
| monitoring = Blood pressure with concurrent antihypertensives or alpha-blockers. | | monitoring = Blood pressure with concurrent antihypertensives or alpha-blockers. | ||
| counseling = Contraindicated with any nitrate. Less visual side effect than sildenafil/vardenafil (higher PDE5 vs PDE6 selectivity). Daily dosing provides continuous coverage | | counseling = Contraindicated with any nitrate. Less visual side effect than sildenafil/vardenafil (higher PDE5 vs PDE6 selectivity). Daily dosing provides continuous coverage, useful for spontaneity and BPH symptoms. | ||
| anecdotes = | | anecdotes = | ||
| seealso = [[Avanafil]], [[Sildenafil]], [[Vardenafil]] | | seealso = [[Avanafil]], [[Sildenafil]], [[Vardenafil]] | ||
Latest revision as of 03:16, 19 May 2026
PDE5 Inhibitor
Tadalafil
Cialis, Adcirca
Tadalafil's distinguishing feature is its long half-life (~17.5 h) and usable duration up to 36 h, hence "the weekend pill." It is the only PDE5 inhibitor FDA-approved for daily use, both for ED and for BPH. 5 mg daily often provides better continuous coverage than 20 mg PRN.
Blood pressure with concurrent antihypertensives or alpha-blockers.
Contraindicated with any nitrate. Less visual side effect than sildenafil/vardenafil (higher PDE5 vs PDE6 selectivity). Daily dosing provides continuous coverage, useful for spontaneity and BPH symptoms.
Avanafil, Sildenafil, Vardenafil
Experience
No personal reports yet
No clinical reports yet
Log in to add your own experience.
Problems
No problems yet. Be the first to suggest one.
+ Add a problemTitration strategies
No titration strategies yet. Be the first to suggest one.
Effects
No effects listed yet. Be the first to suggest one.
Pharmacokinetics
Absorption
Oral; not affected by food (vs sildenafil).Distribution
Plasma protein binding ~94%.Metabolism
Hepatic via CYP3A4.Elimination
Fecal and renal as metabolites.Interactions
No interactions reported yet.
Monitoring
Patient counseling
Relevant anecdote
No anecdotes yet. Share a relevant one.
Relevant Literature
No literature entries yet.
Log in to submit relevant literature.
See also
References
Summary
Classes
PDE5 Inhibitor
Common uses
Erectile dysfunction0, BPH0, Pulmonary arterial hypertension0
Pharmacy
Starting dose
10 mg PRN; 2.5–5 mg daily for continuous coverage / BPH
Preparations
2.5, 5, 10, 20 mg tabs
US FDA Max
20 mg/d (ED, PRN); 5 mg/d (daily / BPH); 40 mg/d (PAH)
Pharmacology
Routes
Oral
Onset
30 min
Duration
Up to 36 h ("the weekend pill")
Half-life
~17.5 h
Bioavailability
Reasonable (not formally established as a percentage)
Pregnancy
Category B
Legal status
Rx-only in US
Purported mechanism
Selective inhibitor of PDE5 with a substantially longer half-life than other PDE5 inhibitors, allowing once-daily continuous dosing.