Testosterone: Difference between revisions
From Pharmacopedia
More actions
| [unchecked revision] | [unchecked revision] |
MDElliottMD (talk | contribs) Create Testosterone scaffold |
MDElliottMD (talk | contribs) Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved. |
||
| (One intermediate revision by the same user not shown) | |||
| Line 12: | Line 12: | ||
| halflife = Highly variable by formulation; native T is hours | | halflife = Highly variable by formulation; native T is hours | ||
| bioavailability = Oral non-undecanoate has essentially zero bioavailability (hepatic first-pass) | | bioavailability = Oral non-undecanoate has essentially zero bioavailability (hepatic first-pass) | ||
| pregnancy = Category X | | pregnancy = Category X, contraindicated; teratogenic (virilization of female fetus) | ||
| legal = Schedule III (DEA, US) | | legal = Schedule III (DEA, US) | ||
| mechanism = Endogenous androgen binding to androgen receptors; mediates male secondary sex characteristics, anabolism, libido, erythropoiesis, and CNS effects on mood/energy/aggression. Aromatized peripherally to estradiol; reduced to DHT. | | mechanism = Endogenous androgen binding to androgen receptors; mediates male secondary sex characteristics, anabolism, libido, erythropoiesis, and CNS effects on mood/energy/aggression. Aromatized peripherally to estradiol; reduced to DHT. | ||
| intro = Testosterone is the principal endogenous androgen and the most prescribed hormone therapy in adult men. Delivered through an unusually wide range of formulations because endogenous half-life is short and oral bioavailability of native testosterone is essentially zero. Off-label use for "low T" symptoms in men with normal levels remains controversial; clear | | intro = Testosterone is the principal endogenous androgen and the most prescribed hormone therapy in adult men. Delivered through an unusually wide range of formulations because endogenous half-life is short and oral bioavailability of native testosterone is essentially zero. Off-label use for "low T" symptoms in men with normal levels remains controversial; clear problems are biochemical hypogonadism and gender-affirming care. | ||
| indications = | | indications = | ||
| dosing = | | dosing = | ||
| Line 27: | Line 27: | ||
| pregnancy_details = Category X. Women of reproductive potential exposed via transdermal partner contact must wash immediately. | | pregnancy_details = Category X. Women of reproductive potential exposed via transdermal partner contact must wash immediately. | ||
| monitoring = Total/free T (timed); H/H (polycythemia); PSA; lipids; LFTs (oral); sleep apnea screen. | | monitoring = Total/free T (timed); H/H (polycythemia); PSA; lipids; LFTs (oral); sleep apnea screen. | ||
| counseling = Avoid skin-to-skin contact with women/children for several hours after gel application. Erythrocytosis is common | | counseling = Avoid skin-to-skin contact with women/children for several hours after gel application. Erythrocytosis is common, monitor hematocrit. Suppresses endogenous production and impairs fertility, discuss sperm banking in patients who may want children. | ||
| anecdotes = | | anecdotes = | ||
| seealso = [[Flibanserin]] | | seealso = [[Flibanserin]] | ||