Enzyme:CYP1A2: Difference between revisions
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MDElliottMD (talk | contribs) Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll... |
MDElliottMD (talk | contribs) Add scope="col" to the data-table column headers for screen-reader association (ADA audit M5; designer-claude 2026-05-22) |
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{| class="wikitable sortable mw-collapsible mw-collapsed" style="width:100%;" | {| class="wikitable sortable mw-collapsible mw-collapsed" style="width:100%;" | ||
|+ style="white-space:nowrap; text-align:left;" | near-complete CYP1A2 substrate table (click to expand) | |+ style="white-space:nowrap; text-align:left;" | near-complete CYP1A2 substrate table (click to expand) | ||
! Substrate !! Therapeutic class !! CYP1A2 contribution !! Clinical notes | ! scope="col" | Substrate !! scope="col" | Therapeutic class !! scope="col" | CYP1A2 contribution !! scope="col" | Clinical notes | ||
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| [[Acetaminophen]] || Analgesic / antipyretic (paracetamol) || minor || At therapeutic doses cleared mostly by conjugation; CYP1A2 contributes to the minor oxidative route that generates the hepatotoxic metabolite NAPQI. | | [[Acetaminophen]] || Analgesic / antipyretic (paracetamol) || minor || At therapeutic doses cleared mostly by conjugation; CYP1A2 contributes to the minor oxidative route that generates the hepatotoxic metabolite NAPQI. | ||