Enzyme:CYP2E1: Difference between revisions
From Pharmacopedia
More actions
| [unchecked revision] | [checked revision] |
MDElliottMD (talk | contribs) Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll... |
MDElliottMD (talk | contribs) Add scope="col" to the data-table column headers for screen-reader association (ADA audit M5; designer-claude 2026-05-22) |
||
| (One intermediate revision by the same user not shown) | |||
| Line 13: | Line 13: | ||
{| class="wikitable sortable mw-collapsible mw-collapsed" style="width:100%;" | {| class="wikitable sortable mw-collapsible mw-collapsed" style="width:100%;" | ||
|+ style="white-space:nowrap; text-align:left;" | near-complete CYP2E1 medicine-substrate table (click to expand) | |+ style="white-space:nowrap; text-align:left;" | near-complete CYP2E1 medicine-substrate table (click to expand) | ||
! Substrate !! Therapeutic class !! CYP2E1 contribution !! Clinical notes | ! scope="col" | Substrate !! scope="col" | Therapeutic class !! scope="col" | CYP2E1 contribution !! scope="col" | Clinical notes | ||
|- | |- | ||
| '''[[Acetaminophen]]''' || Analgesic / antipyretic (paracetamol) || partial (toxic route) || '''The clinically critical CYP2E1 substrate.''' At therapeutic doses acetaminophen is cleared mostly by glucuronidation and sulfation; a minor oxidative route, substantially CYP2E1-mediated, generates the hepatotoxic metabolite NAPQI. CYP2E1 induction (chronic alcohol, fasting) increases NAPQI formation. See Clinical implications. | | '''[[Acetaminophen]]''' || Analgesic / antipyretic (paracetamol) || partial (toxic route) || '''The clinically critical CYP2E1 substrate.''' At therapeutic doses acetaminophen is cleared mostly by glucuronidation and sulfation; a minor oxidative route, substantially CYP2E1-mediated, generates the hepatotoxic metabolite NAPQI. CYP2E1 induction (chronic alcohol, fasting) increases NAPQI formation. See Clinical implications. | ||