Enzyme:CYP3A4: Difference between revisions
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MDElliottMD (talk | contribs) Revise CYP3A4 Phenotype categories section per parser-claude 2026-05-20: the earlier text flatly stated CYP3A4 has no metabolizer-phenotype classification. That is true for CPIC but not for DPWG, which tiers CYP3A4 into PM/IM/NM on the CYP3A4*22 allele. New text states the CPIC/DPWG disagreement, links the three Phenotype:CYP3A4 pages, and keeps the point that environmental induction/inhibition dominate CYP3A4 variability. Cites DPWG guideline PharmGKB PA166265421. See-also gains the three ph... |
MDElliottMD (talk | contribs) Add scope="col" to the data-table column headers for screen-reader association (ADA audit M5; designer-claude 2026-05-22) |
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{| class="wikitable sortable mw-collapsible mw-collapsed" style="width:100%;" | {| class="wikitable sortable mw-collapsible mw-collapsed" style="width:100%;" | ||
|+ style="white-space:nowrap; text-align:left;" | near-complete CYP3A4 substrate table (click to expand) | |+ style="white-space:nowrap; text-align:left;" | near-complete CYP3A4 substrate table (click to expand) | ||
! Substrate !! Therapeutic class !! CYP3A4 contribution !! Clinical notes | ! scope="col" | Substrate !! scope="col" | Therapeutic class !! scope="col" | CYP3A4 contribution !! scope="col" | Clinical notes | ||
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| [[Alfentanil]] || Opioid analgesic (anesthesia) || major || A classic CYP3A4 probe substrate; major substrate of CYP3A4 inhibitor interactions in the operating room. | | [[Alfentanil]] || Opioid analgesic (anesthesia) || major || A classic CYP3A4 probe substrate; major substrate of CYP3A4 inhibitor interactions in the operating room. | ||