Labetalol: Difference between revisions
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{{MedTemplate | {{MedTemplate | ||
| generic = Labetalol | | generic = Labetalol | ||
| classes = Beta blocker | | brand = Trandate, Normodyne (discontinued in US) | ||
| | | structure = | ||
| classes = [[:Category:Beta blockers|Combined alpha-1 and non-selective beta blocker]], [[:Category:Antihypertensives|Antihypertensive]] | |||
| uses = <vote slug="hypertension-use">Hypertension (FDA)</vote>, <vote slug="hypertensive-crisis-use">Hypertensive crisis and severe hypertension (FDA, IV)</vote>, <vote slug="pregnancy-induced-hypertension-use">Hypertension in pregnancy, including preeclampsia and eclampsia (FDA; among the safest antihypertensives in pregnancy)</vote> | |||
| starting_dose = Oral: 100 mg PO BID, titrate to 400 mg BID. IV: 20 mg over 2 minutes, repeat 40-80 mg every 10 minutes as needed (maximum cumulative 300 mg); continuous infusion 2 mg/minute | |||
| preparations = Tablets 100, 200, 300 mg; injection 5 mg/mL | |||
| fda_max = 2400 mg/day (oral); 300 mg total per IV bolus dosing series | |||
| pill_id = | |||
| routes = Oral, intravenous | |||
| onset = BP effect within hours (oral); 5-10 minutes (IV) | |||
| duration = 8-12 hours (oral); 4-6 hours (IV) | |||
| halflife = ~6-8 hours<ref name="trandate-label">FDA Prescribing Information, Trandate (labetalol hydrochloride), Prometheus/Bausch, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/018716s022lbl.pdf</ref> | |||
| bioavailability = ~25% (oral; extensive first-pass)<ref name="trandate-label" /> | |||
| pregnancy = '''Among the safest antihypertensives in pregnancy''', recommended for chronic hypertension during pregnancy and first-line for severe hypertension in preeclampsia and eclampsia<ref name="trandate-label" /> | |||
| legal = [[USLegal:Prescription only|Rx-only]] in US | |||
| mechanism = <vote slug="labetalol-mech-claim">'''Combined α1-adrenergic and non-selective β-adrenergic receptor antagonist''' with approximately 1:3 α:β ratio orally and 1:7 IV. The combined α and β blockade lowers blood pressure through two complementary mechanisms: reduced cardiac output and renin secretion (the β effect, shared with all β-blockers) plus reduced peripheral vascular resistance via vasodilation (the α effect, distinguishing labetalol from selective β-blockers).</vote> The favorable pregnancy safety profile and the dual mechanism support its first-line role in pregnancy-associated hypertension and in hypertensive emergencies where rapid, controllable BP reduction is needed<ref name="trandate-label" />. | |||
}} | }} | ||
== References == | |||
<references /> | |||
[[Category:Beta blockers]] | |||
[[Category:Antihypertensives]] | |||
Latest revision as of 07:27, 23 May 2026
Labetalol
Trandate, Normodyne (discontinued in US)
Experience
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Summary
Common uses
Hypertension (FDA)0, Hypertensive crisis and severe hypertension (FDA, IV)0, Hypertension in pregnancy, including preeclampsia and eclampsia (FDA; among the safest antihypertensives in pregnancy)0
Pharmacy
Starting dose
Oral: 100 mg PO BID, titrate to 400 mg BID. IV: 20 mg over 2 minutes, repeat 40-80 mg every 10 minutes as needed (maximum cumulative 300 mg); continuous infusion 2 mg/minute
Preparations
Tablets 100, 200, 300 mg; injection 5 mg/mL
US FDA Max
2400 mg/day (oral); 300 mg total per IV bolus dosing series
Pharmacology
Routes
Oral, intravenous
Onset
BP effect within hours (oral); 5-10 minutes (IV)
Duration
8-12 hours (oral); 4-6 hours (IV)
Half-life
~6-8 hours[1]
Bioavailability
~25% (oral; extensive first-pass)[1]
Pregnancy
Among the safest antihypertensives in pregnancy, recommended for chronic hypertension during pregnancy and first-line for severe hypertension in preeclampsia and eclampsia[1]
Legal status
Rx-only in US
Purported mechanism
Combined α1-adrenergic and non-selective β-adrenergic receptor antagonist with approximately 1:3 α:β ratio orally and 1:7 IV. The combined α and β blockade lowers blood pressure through two complementary mechanisms: reduced cardiac output and renin secretion (the β effect, shared with all β-blockers) plus reduced peripheral vascular resistance via vasodilation (the α effect, distinguishing labetalol from selective β-blockers).0 The favorable pregnancy safety profile and the dual mechanism support its first-line role in pregnancy-associated hypertension and in hypertensive emergencies where rapid, controllable BP reduction is needed[1].
References
- ↑ 1.0 1.1 1.2 1.3 FDA Prescribing Information, Trandate (labetalol hydrochloride), Prometheus/Bausch, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/018716s022lbl.pdf