Bimatoprost: Difference between revisions
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== References == | == References == | ||
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[[Category:Prostaglandin analogs]] | |||
[[Category:Glaucoma medications]] | |||
[[Category:Ocular hypotensive agents]] | |||
Latest revision as of 10:43, 23 May 2026
Bimatoprost
Lumigan (glaucoma), Latisse (eyelash growth)
Experience
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Summary
Common uses
Primary open-angle glaucoma0, Ocular hypertension0, Eyelash hypotrichosis (Latisse)0
Pharmacy
Starting dose
1 drop in the affected eye(s) once daily in the evening (Lumigan); Latisse applied to upper lash line at bedtime
Preparations
0.01%, 0.03% ophthalmic solution
US FDA Max
One drop per eye per day
Pharmacology
Routes
Topical ophthalmic
Onset
IOP lowering at 4 hours, maximum at 8-12 hours; eyelash effect after 2 months
Duration
24 hours
Half-life
~45 minutes (free acid in aqueous humor)[1]
Bioavailability
Topical; minimal systemic absorption[1]
Pregnancy
Limited data; weigh against alternatives.[citation needed]
Legal status
Rx-only in US
Purported mechanism
Bimatoprost is a prostaglandin F2α analog (technically a prostamide) with potent agonism at the FP-receptor (prostaglandin F2α receptor); FP activation remodels the ciliary muscle extracellular matrix and increases uveoscleral aqueous outflow, lowering intraocular pressure by ~25-35%.0 Like latanoprost, characteristic adverse effects: iris pigmentation darkening (permanent), periocular pigmentation, eyelash growth (the off-label and now FDA-labeled cosmetic indication as Latisse), conjunctival hyperemia, periorbital fat atrophy (sunken upper sulcus, PAP — more pronounced than with latanoprost)[1].
References
- ↑ 1.0 1.1 1.2 FDA Prescribing Information, Lumigan (bimatoprost), Allergan, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022184s007lbl.pdf