Jump to content

Meclizine: Difference between revisions

From Pharmacopedia
[checked revision][checked revision]
← Older edit

MDElliottMD (talk | contribs)

3 user groups
5,189 edits
VisualWikitext
Pharmacopedia: add <pharmaInteractions/>
parser-claude: Meclizine MedTemplate refill, Top 300 stub upgrade
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:
{{MedTemplate
{{MedTemplate
| generic           = Meclizine
| generic           = Meclizine
| brand             = Antivert
| brand             = Antivert (Rx), Bonine (OTC), Dramamine Less Drowsy (OTC)
| structure         =  
| structure         =
| classes           = Antihistamine, Antiemetic
| classes           = [[:Category:Antihistamines|First-generation antihistamine (piperazine)]], [[:Category:Antiemetics|Antiemetic]], [[:Category:Antivertigo medicines|Antivertigo medicine]]
| mechanism          = H1 receptor antagonist
| uses             = <vote slug="motion-sickness-use">Motion sickness prevention (OTC and FDA)</vote>, <vote slug="vertigo-use">Vertigo (FDA)</vote>, <vote slug="meniere-disease-symptomatic-use">Symptomatic Meniere disease (off-label)</vote>
| uses               =  
| starting_dose     = Motion sickness: 25-50 mg PO 1 hour before travel, repeat every 24 hours as needed. Vertigo: 25-100 mg/day divided
| starting_dose     =  
| preparations     = Tablets 12.5, 25 mg; chewable tablets 25 mg
| preparations       =  
| fda_max           = 100 mg/day (vertigo)
| fda_max          =  
| pill_id           =
| routes             =  
| routes           = Oral
| onset             =  
| onset             = ~1 hour
| duration           =  
| duration         = 12-24 hours (long for an antihistamine)
| halflife           =  
| halflife         = ~6 hours<ref name="antivert-label">FDA Prescribing Information, Antivert (meclizine hydrochloride), Pfizer/various, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/010721s059lbl.pdf</ref>
| bioavailability   =  
| bioavailability   = ~25% (oral)<ref name="antivert-label" />
| pregnancy         =  
| pregnancy         = Older agent with substantial use experience; observational signals reassuring for first-trimester exposure.{{citation needed}}
| legal             =  
| legal             = [[USLegal:Over-the-counter|OTC]] as Bonine and Dramamine Less Drowsy; [[USLegal:Prescription only|Rx-only]] as Antivert
| intro              =
| mechanism        = <vote slug="meclizine-mech-claim">First-generation H1 receptor antagonist with central nervous system penetration. Additional moderate anticholinergic activity contributes to the antiemetic and antivertigo effects, acting at central vestibular pathways and the chemoreceptor trigger zone of the area postrema. Less sedating than diphenhydramine on a milligram basis, but more sedating than the second-generation non-sedating antihistamines.</vote> Anticholinergic burden (dry mouth, blurred vision, urinary retention, cognitive effects) is the principal adverse-event concern and the basis for Beers-list cautions in elderly patients<ref name="antivert-label" />.
| pharmacokinetics  =
| pharmacodynamics  =  
| indications        =  
| dosing            =
| effects           =
| interactions      = <pharmaInteractions/>
| pregnancy_details  =
| monitoring        =
| counseling        =
| anecdotes          =
| seealso            =
| references        =  
}}
}}
== References ==
<references />


[[Category:Antihistamines]]
[[Category:Antihistamines]]
[[Category:Antiemetics]]
[[Category:Antivertigo medicines]]

Latest revision as of 07:04, 23 May 2026

First-generation antihistamine (piperazine), Antiemetic, Antivertigo medicine
Meclizine
Antivert (Rx), Bonine (OTC), Dramamine Less Drowsy (OTC)

Experience

👥 No personal reports yet
⚕ No clinical reports yet

Log in to add your own experience.

Problems

No problems yet. Be the first to suggest one.

+ Add a problem

Titration strategies

No titration strategies yet. Be the first to suggest one.

+ Add a titration strategy

Effects

No effects listed yet. Be the first to suggest one.

+ Add an effect

Relevant anecdote

No anecdotes yet. Share a relevant one.

+ Add an anecdote

Relevant Literature

No literature entries yet.

Log in to submit relevant literature.

Summary
Classes
First-generation antihistamine (piperazine), Antiemetic, Antivertigo medicine
Common uses
Motion sickness prevention (OTC and FDA)0, Vertigo (FDA)0, Symptomatic Meniere disease (off-label)0
Pharmacy
Starting dose
Motion sickness: 25-50 mg PO 1 hour before travel, repeat every 24 hours as needed. Vertigo: 25-100 mg/day divided
Preparations
Tablets 12.5, 25 mg; chewable tablets 25 mg
US FDA Max
100 mg/day (vertigo)
Pharmacology
Routes
Oral
Onset
~1 hour
Duration
12-24 hours (long for an antihistamine)
Half-life
~6 hours[1]
Bioavailability
~25% (oral)[1]
Pregnancy
Older agent with substantial use experience; observational signals reassuring for first-trimester exposure.[citation needed]
Legal status
OTC as Bonine and Dramamine Less Drowsy; Rx-only as Antivert
Purported mechanism
First-generation H1 receptor antagonist with central nervous system penetration. Additional moderate anticholinergic activity contributes to the antiemetic and antivertigo effects, acting at central vestibular pathways and the chemoreceptor trigger zone of the area postrema. Less sedating than diphenhydramine on a milligram basis, but more sedating than the second-generation non-sedating antihistamines.0 Anticholinergic burden (dry mouth, blurred vision, urinary retention, cognitive effects) is the principal adverse-event concern and the basis for Beers-list cautions in elderly patients[1].

References

  1. ↑ 1.0 1.1 1.2 FDA Prescribing Information, Antivert (meclizine hydrochloride), Pfizer/various, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/010721s059lbl.pdf
Retrieved from "https://pharmacopedia.wiki/index.php?title=Meclizine&oldid=6682"