Category:PDE5 Inhibitors: Difference between revisions
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MDElliottMD (talk | contribs) Category taxonomy ship: add Category:Non-psychotropic medicines |
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== Class members == | == Class members == | ||
* [[Sildenafil]] (Viagra, Revatio) | * [[Sildenafil]] (Viagra, Revatio), first-in-class, FDA-approved 1998, half-life ~4 h | ||
* [[Vardenafil]] (Levitra, Staxyn) | * [[Vardenafil]] (Levitra, Staxyn), similar profile to sildenafil | ||
* [[Tadalafil]] (Cialis, Adcirca) | * [[Tadalafil]] (Cialis, Adcirca), long-acting, half-life ~17.5 h ("weekend pill") | ||
* [[Avanafil]] (Stendra) | * [[Avanafil]] (Stendra), newer, faster onset (~15 min), more selective | ||
== Universal warnings == | == Universal warnings == | ||
* '''Absolutely contraindicated with any nitrate''' | * '''Absolutely contraindicated with any nitrate''', life-threatening hypotension | ||
* Caution with alpha-blockers | * Caution with alpha-blockers, separate doses by ≥4 h | ||
* Avoid in patients where sexual activity itself is contraindicated by cardiovascular instability | * Avoid in patients where sexual activity itself is contraindicated by cardiovascular instability | ||
* All metabolized through CYP3A4 | * All metabolized through CYP3A4, strong inhibitors (azoles, protease inhibitors) raise levels | ||
[[Category:MedCategory]] | [[Category:MedCategory]] | ||
[[Category:Medicines]] | [[Category:Medicines]] | ||
[[Category:Pharmaceutical]] | |||
[[Category:Non-psychotropic medicines]] | |||