Methamphetamine: Difference between revisions
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MDElliottMD (talk | contribs) Comprehensive categorization: +Phenethylamines |
MDElliottMD (talk | contribs) Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved. |
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| pregnancy = Category C (per Desoxyn label) | | pregnancy = Category C (per Desoxyn label) | ||
| legal = Schedule II | | legal = Schedule II | ||
| mechanism = Monoamine releasing agent | | mechanism = Monoamine releasing agent, TAAR1 agonism, VMAT2 substrate, DAT/NET reverse transport | ||
| intro = '''Methamphetamine''' is a CNS stimulant of the amphetamine class. It is FDA-approved (as '''Desoxyn''') for attention-deficit hyperactivity disorder and short-term management of obesity. It is a Schedule II controlled substance in the United States. | | intro = '''Methamphetamine''' is a CNS stimulant of the amphetamine class. It is FDA-approved (as '''Desoxyn''') for attention-deficit hyperactivity disorder and short-term management of obesity. It is a Schedule II controlled substance in the United States. | ||
| indications = < | | indications = <problem slug="adhd" title="ADHD in children, adolescents, and adults" author="MDElliottMD"/> | ||
< | <problem slug="obesity" title="Obesity (short-term)" author="MDElliottMD"/> | ||
| dosing = | effects = | | dosing = | effects = | ||
* <effect ref="attention" author="MDElliottMD"/> | * <effect ref="attention" author="MDElliottMD"/> | ||
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| pk_elimination = Urinary elimination is pH-dependent. | | pk_elimination = Urinary elimination is pH-dependent. | ||
| pharmacodynamics = Methamphetamine acts at monoaminergic terminals as a releasing agent via TAAR1 agonism, VMAT2 substrate activity, and DAT/NET reverse transport. Secondary mechanisms include weak monoamine reuptake inhibition. | | pharmacodynamics = Methamphetamine acts at monoaminergic terminals as a releasing agent via TAAR1 agonism, VMAT2 substrate activity, and DAT/NET reverse transport. Secondary mechanisms include weak monoamine reuptake inhibition. | ||
| interactions = * '''MAOIs''' | | interactions = * '''MAOIs''', contraindicated (per label) | ||
* '''Acidifying agents''' | * '''Acidifying agents''', increase urinary clearance | ||
* '''Alkalinizing agents''' | * '''Alkalinizing agents''', decrease urinary clearance | ||
<pharmaInteractions/> | <pharmaInteractions/> | ||
| pregnancy_details = Category C per Desoxyn label. | | pregnancy_details = Category C per Desoxyn label. | ||
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[[Category: | [[Category:Psychostimulants]] | ||
[[Category:Amphetamines]] | [[Category:Amphetamines]] | ||
[[Category:Psychostimulants]] | [[Category:Psychostimulants]] | ||
[[Category:Phenethylamines]] | [[Category:Phenethylamines]] | ||