Coca: Difference between revisions
| [unchecked revision] | [unchecked revision] |
Pendell's corner: replace paraphrase with verbatim passage (Dynamis) |
MDElliottMD (talk | contribs) Category taxonomy ship: retag plant categories -> Plants |
||
| (One intermediate revision by the same user not shown) | |||
| Line 7: | Line 7: | ||
| routes = Oral (leaf, buccal); refined cocaine has its own profile | | routes = Oral (leaf, buccal); refined cocaine has its own profile | ||
| mechanism = Primary alkaloid is cocaine, a tropane that blocks reuptake of dopamine and norepinephrine (and serotonin). At low oral doses from leaf chewing, the slow release favors NE-mediated alertness over DA-mediated euphoria. | | mechanism = Primary alkaloid is cocaine, a tropane that blocks reuptake of dopamine and norepinephrine (and serotonin). At low oral doses from leaf chewing, the slow release favors NE-mediated alertness over DA-mediated euphoria. | ||
| intro = Coca is the leaf of ''Erythroxylum coca'' (and the related ''E. novogranatense''), cultivated for at least 5,000 years across the Andes. Two ounces of dried leaves (a day's traditional ration) contain ~600 mg cocaine | | intro = Coca is the leaf of ''Erythroxylum coca'' (and the related ''E. novogranatense''), cultivated for at least 5,000 years across the Andes. Two ounces of dried leaves (a day's traditional ration) contain ~600 mg cocaine, biologically meaningful, but the leaf-chewing route produces a steady alertness rather than the euphoric spike of refined cocaine. Also a nutrient source: 100 g coca leaf = 300 calories + 18.9 g protein + 100% RDA Ca/Fe/P/B2. | ||
| legal = Leaves legal in Bolivia, Peru, Colombia; cocaine internationally controlled | | legal = Leaves legal in Bolivia, Peru, Colombia; cocaine internationally controlled | ||
| seealso = [[Cocaine]], [[Amphetamine]] | | seealso = [[Cocaine]], [[Amphetamine]] | ||
| Line 19: | Line 19: | ||
[[Category:Excitantia]] | [[Category:Excitantia]] | ||
[[Category: | [[Category:Plants]] | ||
[[Category:Medicines]] | [[Category:Medicines]] | ||
Latest revision as of 00:38, 22 May 2026
Plant Medicine, Excitantia
Coca
Erythroxylum coca, E. novogranatense
Coca is the leaf of Erythroxylum coca (and the related E. novogranatense), cultivated for at least 5,000 years across the Andes. Two ounces of dried leaves (a day's traditional ration) contain ~600 mg cocaine, biologically meaningful, but the leaf-chewing route produces a steady alertness rather than the euphoric spike of refined cocaine. Also a nutrient source: 100 g coca leaf = 300 calories + 18.9 g protein + 100% RDA Ca/Fe/P/B2.
Cocaine, Amphetamine
Experience
No personal reports yet
No clinical reports yet
Log in to add your own experience.
Problems
No problems yet. Be the first to suggest one.
+ Add a problemTitration strategies
No titration strategies yet. Be the first to suggest one.
Effects
No effects listed yet. Be the first to suggest one.
Relevant anecdote
No anecdotes yet. Share a relevant one.
Relevant Literature
No literature entries yet.
Log in to submit relevant literature.
See also
References
Summary
Classes
Plant Medicine, Excitantia
Common uses
Alertness0, Altitude sickness0, Endurance0, Appetite suppression0
Pharmacy
Preparations
Leaves chewed with a pinch of slaked lime (the lime converts cocaine HCl to freebase for buccal absorption); also drunk as tea (mate de coca)
Pharmacology
Routes
Oral (leaf, buccal); refined cocaine has its own profile
Legal status
Leaves legal in Bolivia, Peru, Colombia; cocaine internationally controlled
Purported mechanism
Primary alkaloid is cocaine, a tropane that blocks reuptake of dopamine and norepinephrine (and serotonin). At low oral doses from leaf chewing, the slow release favors NE-mediated alertness over DA-mediated euphoria.
“Pendell's corner
Even in the Andes, the stimulant had a punctuating function. The quid itself is a measure of time, distances measured by the number of chews required to traverse the terrain.
— Dale Pendell, Pharmako/Dynamis