Zavzpret: Difference between revisions
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[[Category:Gepants]] | [[Category:Gepants (CGRP Receptor Antagonists)]] | ||
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Latest revision as of 00:37, 22 May 2026
Gepant, CGRP receptor antagonist
Zavzpret
Zavzpret (zavegepant)
Zavzpret (zavegepant) is the first intranasally administered CGRP receptor antagonist (gepant), FDA-approved in March 2023 for the acute treatment of migraine in adults. Its nasal route delivers faster onset than oral gepants, useful when nausea precludes pills.
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Summary
Classes
Gepant, CGRP receptor antagonist
Common uses
Acute treatment of migraine with or without aura in adults
Pharmacy
Starting dose
10 mg (one spray) intranasally in one nostril
Preparations
10 mg/spray nasal solution
US FDA Max
10 mg per 24 h
Pharmacology
Routes
Intranasal
Onset
Pain relief reported within 15 min in trials
Duration
~48 h sustained pain freedom in responders
Half-life
~6.6 h
Bioavailability
~5% intranasal
Pregnancy
Limited data; avoid
Legal status
Rx
Purported mechanism
Small-molecule CGRP receptor antagonist; intranasal formulation