Methamphetamine: Difference between revisions
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| pregnancy = Category C (per Desoxyn label) | | pregnancy = Category C (per Desoxyn label) | ||
| legal = Schedule II | | legal = Schedule II | ||
| mechanism = Monoamine releasing agent | | mechanism = Monoamine releasing agent, TAAR1 agonism, VMAT2 substrate, DAT/NET reverse transport | ||
| intro = '''Methamphetamine''' is a CNS stimulant of the amphetamine class. It is FDA-approved (as '''Desoxyn''') for attention-deficit hyperactivity disorder and short-term management of obesity. It is a Schedule II controlled substance in the United States. | | intro = '''Methamphetamine''' is a CNS stimulant of the amphetamine class. It is FDA-approved (as '''Desoxyn''') for attention-deficit hyperactivity disorder and short-term management of obesity. It is a Schedule II controlled substance in the United States. | ||
| indications = <problem slug="adhd" title="ADHD in children, adolescents, and adults" author="MDElliottMD"/> | | indications = <problem slug="adhd" title="ADHD in children, adolescents, and adults" author="MDElliottMD"/> | ||
| Line 50: | Line 50: | ||
| pk_elimination = Urinary elimination is pH-dependent. | | pk_elimination = Urinary elimination is pH-dependent. | ||
| pharmacodynamics = Methamphetamine acts at monoaminergic terminals as a releasing agent via TAAR1 agonism, VMAT2 substrate activity, and DAT/NET reverse transport. Secondary mechanisms include weak monoamine reuptake inhibition. | | pharmacodynamics = Methamphetamine acts at monoaminergic terminals as a releasing agent via TAAR1 agonism, VMAT2 substrate activity, and DAT/NET reverse transport. Secondary mechanisms include weak monoamine reuptake inhibition. | ||
| interactions = * '''MAOIs''' | | interactions = * '''MAOIs''', contraindicated (per label) | ||
* '''Acidifying agents''' | * '''Acidifying agents''', increase urinary clearance | ||
* '''Alkalinizing agents''' | * '''Alkalinizing agents''', decrease urinary clearance | ||
<pharmaInteractions/> | <pharmaInteractions/> | ||
| pregnancy_details = Category C per Desoxyn label. | | pregnancy_details = Category C per Desoxyn label. | ||
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[[Category: | [[Category:Psychostimulants]] | ||
[[Category:Amphetamines]] | [[Category:Amphetamines]] | ||
[[Category:Psychostimulants]] | [[Category:Psychostimulants]] | ||
[[Category:Phenethylamines]] | [[Category:Phenethylamines]] | ||
Latest revision as of 03:16, 19 May 2026
Psychostimulant, Amphetamine
Methamphetamine
Desoxyn
Methamphetamine is a CNS stimulant of the amphetamine class. It is FDA-approved (as Desoxyn) for attention-deficit hyperactivity disorder and short-term management of obesity. It is a Schedule II controlled substance in the United States.
+ Add a problem
Methamphetamine acts at monoaminergic terminals as a releasing agent via TAAR1 agonism, VMAT2 substrate activity, and DAT/NET reverse transport. Secondary mechanisms include weak monoamine reuptake inhibition.
Category C per Desoxyn label.
Mixed amphetamine salts, Dextroamphetamine, Lisdexamfetamine, Methylphenidate, Dexmethylphenidate, Modafinil
Experience
No personal reports yet
No clinical reports yet
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Problems
Obesity (short-term)— 1 don't know
Titration strategies
No titration strategies yet. Be the first to suggest one.
Effects
- Attention and focus no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Wakefulness no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Motivation and drive no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Mild euphoria no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Decreased appetite/Anorexia no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Dry mouth no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Elevated heart rate / blood pressure no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Insomnia no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Irritability no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Anxiety no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Headache no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Weight loss no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Palpitations no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Jaw clenching / bruxism no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Stereotyped behaviors no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Agitation no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Psychosis no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Mania no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Dependence / misuse no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Tolerance no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Serious cardiac event no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Seizure/Epileptic fit no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Hyperthermia no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Serotonin syndrome no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Withdrawal/Discontinuation Syndrome no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
Pharmacokinetics
Metabolism
Hepatic metabolism includes N-demethylation to amphetamine (an active metabolite).Elimination
Urinary elimination is pH-dependent.Pharmacodynamics
Interactions
- MAOIs, contraindicated (per label)
- Acidifying agents, increase urinary clearance
- Alkalinizing agents, decrease urinary clearance
No interactions reported yet.
Pregnancy and lactation
Relevant anecdote
No anecdotes yet. Share a relevant one.
Relevant Literature
No literature entries yet.
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See also
References
Summary
Classes
Psychostimulant, Amphetamine
Common uses
Inattention0, Hyperactivity0, Obesity0
Pharmacy
Starting dose
5 mg PO
Preparations
Desoxyn 5 mg tabs
US FDA Max
25 mg/day (ADHD per Desoxyn label); 15 mg/day (obesity, short-term, per Desoxyn label)
Pharmacology
Routes
Oral (prescribed)
Pregnancy
Category C (per Desoxyn label)
Legal status
Schedule II
Purported mechanism
Monoamine releasing agent, TAAR1 agonism, VMAT2 substrate, DAT/NET reverse transport