Nebivolol: Difference between revisions
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MDElliottMD (talk | contribs) Sweep: "indications" -> "problems" sitewide terminology update (preserves MedTemplate param name) |
MDElliottMD (talk | contribs) Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved. |
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| legal = Rx-only in US | | legal = Rx-only in US | ||
| mechanism = The d-enantiomer is a highly β1-selective antagonist; the l-enantiomer triggers endothelial nitric-oxide–mediated vasodilation. Unique among beta blockers for this NO mechanism. | | mechanism = The d-enantiomer is a highly β1-selective antagonist; the l-enantiomer triggers endothelial nitric-oxide–mediated vasodilation. Unique among beta blockers for this NO mechanism. | ||
| intro = Nebivolol is a third-generation beta blocker with two stereoisomers: d-nebivolol provides highly β1-selective blockade, while l-nebivolol releases endothelial NO and produces direct vasodilation. The result is a favorable side-effect profile relative to older beta blockers | | intro = Nebivolol is a third-generation beta blocker with two stereoisomers: d-nebivolol provides highly β1-selective blockade, while l-nebivolol releases endothelial NO and produces direct vasodilation. The result is a favorable side-effect profile relative to older beta blockers, less fatigue, less sexual dysfunction, and even some evidence of improved erectile function. FDA-approved only for hypertension in the US. | ||
| indications = | | indications = | ||
| dosing = | | dosing = | ||
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| pregnancy_details = | | pregnancy_details = | ||
| monitoring = Heart rate, blood pressure | | monitoring = Heart rate, blood pressure | ||
| counseling = Do not stop abruptly. Tolerated well by many patients who can't tolerate other beta blockers, but the FDA problem is HTN only | | counseling = Do not stop abruptly. Tolerated well by many patients who can't tolerate other beta blockers, but the FDA problem is HTN only, off-label use in HF lacks the trial evidence of metoprolol succinate / bisoprolol / carvedilol. | ||
| anecdotes = | | anecdotes = | ||
| seealso = [[Metoprolol]], [[Bisoprolol]], [[Propranolol]] | | seealso = [[Metoprolol]], [[Bisoprolol]], [[Propranolol]] | ||