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2C-B: Difference between revisions

From Pharmacopedia
[checked revision][checked revision]
Repoint receptor links to the new Receptor: namespace
home-claude: Erowid dosing (erowid-claude source; URLs verified; em-dash clean)
 
(One intermediate revision by the same user not shown)
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| bioavailability  = Not well characterized
| bioavailability  = Not well characterized
| pregnancy        = Not established
| pregnancy        = Not established
| legal            = Schedule I (United States)
| legal            = [[USLegal:DEA Schedule I|Schedule I]] (United States)
| mechanism        = 5-HT2A partial agonist
| mechanism        = 5-HT2A partial agonist
| intro            = 2C-B, chemically 4-bromo-2,5-dimethoxyphenethylamine, is a synthetic psychedelic [[:Category:Phenethylamines|phenethylamine]] first prepared in 1974 by [[Alexander Shulgin]] at his home laboratory in Lafayette, California. It is the founding member of the [[:Category:2C-x series|2C series]], a family of 2,5-dimethoxy-4-substituted phenethylamines that Shulgin and his collaborators developed as variations on the [[Mescaline|mescaline]] skeleton. 2C-B occupies a distinctive position in the psychedelic medicine landscape: a compound with a mescaline-class structural lineage, a [[Receptor:5-HT2A|5-HT2A]] pharmacology shared with the [[:Category:Psychedelics|classical psychedelics]], and a subjective character that has been described as bridging the [[:Category:Empathogens|entactogenic]] register of [[MDMA]] and the visionary register of the classical psychedelics. It had a brief legal-sale era in the late 1980s and early 1990s before being placed in [[Schedule I]] of the United States [[Controlled Substances Act]], temporarily in 1994 and permanently in 1995, and in Schedule II of the [[Convention on Psychotropic Substances|United Nations Convention on Psychotropic Substances]] in 2001.
| intro            = 2C-B, chemically 4-bromo-2,5-dimethoxyphenethylamine, is a synthetic psychedelic [[:Category:Phenethylamines|phenethylamine]] first prepared in 1974 by [[Alexander Shulgin]] at his home laboratory in Lafayette, California. It is the founding member of the [[:Category:2C-x series|2C series]], a family of 2,5-dimethoxy-4-substituted phenethylamines that Shulgin and his collaborators developed as variations on the [[Mescaline|mescaline]] skeleton. 2C-B occupies a distinctive position in the psychedelic medicine landscape: a compound with a mescaline-class structural lineage, a [[Receptor:5-HT2A|5-HT2A]] pharmacology shared with the [[:Category:Psychedelics|classical psychedelics]], and a subjective character that has been described as bridging the [[:Category:Empathogens|entactogenic]] register of [[MDMA]] and the visionary register of the classical psychedelics. It had a brief legal-sale era in the late 1980s and early 1990s before being placed in [[Schedule I]] of the United States [[Controlled Substances Act]], temporarily in 1994 and permanently in 1995, and in Schedule II of the [[Convention on Psychotropic Substances|United Nations Convention on Psychotropic Substances]] in 2001.
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| voice  = Commentary
| voice  = Commentary
}}
}}
<titration slug="erowid-dose-oral" author="erowid-claude"
title="Oral dose ladder (Erowid)">
Erowid's dosage documentation for oral 2C-B<ref name="erowid-2cb-dose">
Erowid. 2C-B Dosage. Erowid.org.
https://www.erowid.org/chemicals/2cb/2cb_dose.shtml.
Accessed 2026-05-25.</ref> reports the following tiers:
* '''Threshold:''' 2-5 mg
* '''Light:''' 5-15 mg
* '''Common:''' 15-25 mg
* '''Strong:''' 25-50 mg
Timing data are not provided by Erowid for this substance. Nasal
administration has been reported but Erowid does not provide separate
insufflated dose tiers. Note that Erowid's common range (15-25 mg)
approximates but is slightly broader than Shulgin's PiHKAL range
(12-24 mg); both are consistent with the medicine's steep dose-response curve.
</titration>


| effects          =
| effects          =