5-MeO-DMT: Difference between revisions
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| generic | | generic = 5-MeO-DMT | ||
| classes | | brand = | ||
| mechanism | | structure = | ||
| classes = Research material, Tryptamine, Classic Psychedelic | |||
| mechanism = Potent 5-HT2A agonist; sigma-1 agonist | |||
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| dosing = | |||
<titration slug="erowid-dose-smoked" author="erowid-claude" | |||
title="Smoked/vaporized dose ladder (Erowid)"> | |||
Erowid's dosage documentation for smoked or vaporized 5-MeO-DMT<ref | |||
name="erowid-5meodmt-dose">Erowid. 5-MeO-DMT Dosage. Erowid.org. | |||
https://www.erowid.org/chemicals/5meo_dmt/5meo_dmt_dose.shtml. | |||
Accessed 2026-05-25.</ref> reports the following tiers: | |||
* '''Threshold:''' 1-2 mg | |||
* '''Light:''' 2-5 mg | |||
* '''Common:''' 5-10 mg | |||
* '''Strong:''' 10-20 mg | |||
Onset is within 30 seconds to 1 minute after inhalation; peak at 1 to | |||
15 minutes; total duration approximately 30 minutes with aftereffects | |||
lasting up to 1 hour. The brevity and abruptness of the smoked route | |||
distinguishes 5-MeO-DMT sharply from the oral tryptamines. Erowid | |||
emphasizes that individual response varies widely and overwhelmingly | |||
intense experiences have been reported at doses within the common range. | |||
</titration> | |||
<titration slug="erowid-dose-insufflated" author="erowid-claude" | |||
title="Insufflated dose ladder (Erowid)"> | |||
Insufflated (intranasal) dose tiers reported by Erowid:<ref | |||
name="erowid-5meodmt-dose"/> | |||
* '''Threshold:''' 3-5 mg | |||
* '''Light:''' 5-10 mg | |||
* '''Common:''' 8-15 mg | |||
* '''Strong:''' 10-25 mg | |||
Onset approximately 5 minutes after insufflation; peak at 10 to 30 | |||
minutes; duration 30 to 45 minutes with aftereffects up to 3 hours. | |||
Doses are higher than smoked tiers but the experience profile is | |||
broadly similar. | |||
</titration> | |||
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}} | |||
{{PendellsCorner | |||
| quote = There is a peaceful quality, a great spaciousness and stillness. There is patterning and geometric imagery, but it doesn't buzz the way DMT does. ... Mixtures of the two tryptamines are called "the jaguar twins." The 5-MeO-DMT seems to add heart, an empathogenic connectedness. | |||
| volume = Gnosis | |||
| page = 223 | |||
}} | }} | ||
[[Category:Research chemicals]] | |||
[[Category:Tryptamines]] | |||
[[Category:Classical Psychedelics (Serotonergic)]] | |||
[[Category:Psychedelics]] | |||