Liothyronine: Difference between revisions
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| halflife = ~1 day (much shorter than T4's ~7 days)<ref name="cytomel-label">FDA Prescribing Information, Cytomel (liothyronine sodium), Pfizer/King, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/010379s055lbl.pdf</ref> | | halflife = ~1 day (much shorter than T4's ~7 days)<ref name="cytomel-label">FDA Prescribing Information, Cytomel (liothyronine sodium), Pfizer/King, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/010379s055lbl.pdf</ref> | ||
| bioavailability = ~95% (oral)<ref name="cytomel-label" /> | | bioavailability = ~95% (oral)<ref name="cytomel-label" /> | ||
| pregnancy = T4 (levothyroxine) is the first-line in pregnancy; T3 is rarely needed. | | pregnancy = T4 (levothyroxine) is the first-line in pregnancy; T3 is rarely needed.<ref name="ata2017-preg">Alexander EK, Pearce EN, Brent GA, et al. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017;27(3):315-389. PMID 28056690.</ref> | ||
| legal = [[USLegal:Prescription only|Rx-only]] in US | | legal = [[USLegal:Prescription only|Rx-only]] in US | ||
| mechanism = <vote slug="liothyronine-mech-claim">Liothyronine is bioidentical T3 (triiodothyronine), the active thyroid hormone that binds nuclear thyroid hormone receptors with ~10× the affinity of T4; T4 (levothyroxine) is essentially a prodrug peripherally deiodinated to T3.</vote> Direct T3 supplementation bypasses peripheral deiodination, useful in myxedema coma (rapid clinical effect needed) and in some refractory hypothyroidism (combination T4+T3, controversial). Short half-life produces fluctuating serum levels with intermittent supraphysiologic peaks — one reason T4 monotherapy remains the practical standard<ref name="cytomel-label" />. | | mechanism = <vote slug="liothyronine-mech-claim">Liothyronine is bioidentical T3 (triiodothyronine), the active thyroid hormone that binds nuclear thyroid hormone receptors with ~10× the affinity of T4; T4 (levothyroxine) is essentially a prodrug peripherally deiodinated to T3.</vote> Direct T3 supplementation bypasses peripheral deiodination, useful in myxedema coma (rapid clinical effect needed) and in some refractory hypothyroidism (combination T4+T3, controversial). Short half-life produces fluctuating serum levels with intermittent supraphysiologic peaks — one reason T4 monotherapy remains the practical standard<ref name="cytomel-label" />. | ||