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Haloperidol: Difference between revisions

From Pharmacopedia
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Pharmacopedia: remove contraindications parameter
Line 43: Line 43:
* '''Lowered seizure threshold''' — caution in epilepsy
* '''Lowered seizure threshold''' — caution in epilepsy
* '''Black box warning:''' increased mortality in elderly patients with dementia-related psychosis
* '''Black box warning:''' increased mortality in elderly patients with dementia-related psychosis
| contraindications = * Severe CNS depression or coma
* Parkinson's disease (worsens motor symptoms)
* Lewy body dementia (severe neuroleptic sensitivity — can be fatal)
* Known QT prolongation or torsades de pointes risk
* Hypersensitivity to haloperidol or butyrophenones
| interactions      = * '''QT-prolonging agents''' — azoles, fluoroquinolones, methadone, ondansetron, citalopram, certain antiarrhythmics — additive risk of torsades
| interactions      = * '''QT-prolonging agents''' — azoles, fluoroquinolones, methadone, ondansetron, citalopram, certain antiarrhythmics — additive risk of torsades
* '''CYP3A4 inhibitors''' (ketoconazole, ritonavir, clarithromycin) — elevated haloperidol levels
* '''CYP3A4 inhibitors''' (ketoconazole, ritonavir, clarithromycin) — elevated haloperidol levels