Alprazolam: Difference between revisions

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 * '''Suicide risk in overdose''' — especially when combined with alcohol or opioids.
 * '''Rebound anxiety''' between doses with short-half-life IR formulation.
-| contraindications = * Acute narrow-angle glaucoma
-* Severe respiratory insufficiency (including untreated sleep apnea)
-* Severe hepatic impairment
-* Concurrent strong CYP3A4 inhibitors (ketoconazole, itraconazole) — contraindicated per FDA labeling
-* Known hypersensitivity to alprazolam or benzodiazepines
-* Caution: history of substance use disorder, myasthenia gravis, pregnancy
 | interactions      = * '''Opioids''' — additive respiratory depression and overdose risk ('''FDA black box warning'''); avoid when possible
 * '''Alcohol''' — additive CNS depression and respiratory depression