Fluoxetine: Difference between revisions
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| starting_dose = 10 mg | | starting_dose = 10 mg | ||
| preparations = 10 mg, 20 mg, 40 mg caps | | preparations = 10 mg, 20 mg, 40 mg caps | ||
| routes = Oral | | routes = Oral | ||
| onset = | | onset = | ||
| duration = Very long | | duration = Very long | ||
| halflife = 1-4 days (7-15 days for norfluoxetine) | | halflife = 1-4 days (7-15 days for norfluoxetine) | ||
| bioavailability = 70-90% | | bioavailability = 70-90% (Oral) | ||
| pregnancy = Category C | | pregnancy = [https://www.ncbi.nlm.nih.gov/books/NBK501186/ Category C] | ||
| legal = Rx-only | | legal = Rx-only | ||
| mechanism = [https://pmc.ncbi.nlm.nih.gov/articles/PMC9666396/ TrkB/BDNF] <vote slug="test1">Fluoxetine is a selective serotonin reuptake inhibitor.</vote> | | mechanism = [https://pmc.ncbi.nlm.nih.gov/articles/PMC9666396/ TrkB/BDNF] <vote slug="test1">Fluoxetine is a selective serotonin reuptake inhibitor.</vote> | ||
| intro = Fluoxetine | | intro = Fluoxetine was the first to be released of a long line of subsequent SSRIs. It is remarkable in its extremely long half life and relative lack of withdrawal syndrome. It can also be very useful it helping taper and terminate other SxRI medicines. | ||
| pharmacokinetics = | | pharmacokinetics = | ||
| indications = Anxiety disorders broadly, including panic attacks, social anxiety, | | pharmacodynamics = | ||
| indications = Anxiety disorders broadly, including panic attacks, social anxiety, | |||
| dosing = Start no higher than 10 mg for first dose! Participant may increase by 10 mg every 2-12 weeks, or never increase if they are satisfied with the 10 mg effect.<discuss slug="titration-discussion"/> | | dosing = Start no higher than 10 mg for first dose! Participant may increase by 10 mg every 2-12 weeks, or never increase if they are satisfied with the 10 mg effect.<discuss slug="titration-discussion"/> | ||
| effects = <effect slug="anxiolysis" label="Anxiolysis">Classically starting at 3-4 weeks and improving for another 8-12</effect> | | effects = <effect slug="anxiolysis" label="Anxiolysis">Classically starting at 3-4 weeks and improving for another 8-12</effect> | ||
| Line 26: | Line 25: | ||
</effect><effect slug="nausea" label="Nausea">Common, often improves over 1-2 weeks.</effect> | </effect><effect slug="nausea" label="Nausea">Common, often improves over 1-2 weeks.</effect> | ||
<effect slug="sexual-dysfunction" label="Sexual dysfunction">Frequent; can persist long-term.</effect> | <effect slug="sexual-dysfunction" label="Sexual dysfunction">Frequent; can persist long-term.</effect> | ||
| contraindications = | | contraindications = | ||
| interactions = | | interactions = | ||
| pregnancy_details = | | pregnancy_details = | ||
| monitoring = | | monitoring = | ||
| counseling = | | counseling = | ||
| anecdotes = | | anecdotes = | ||
Revision as of 22:09, 12 May 2026
SSRI, Anxiolytic, Antidepressant
Fluoxetine
Prozac
Fluoxetine was the first to be released of a long line of subsequent SSRIs. It is remarkable in its extremely long half life and relative lack of withdrawal syndrome. It can also be very useful it helping taper and terminate other SxRI medicines.
Start no higher than 10 mg for first dose! Participant may increase by 10 mg every 2-12 weeks, or never increase if they are satisfied with the 10 mg effect.
Experience
No personal reports yet
1 provider report · avg efficacy 40.0/100 · avg side-effect burden 40.0/100 · 150 patients managed total
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Problems
Anxiety disorders broadly, including panic attacks, social anxiety,
+ Add a problemTitration strategies
Discussion (0)
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Effects
Anxiolysis no reports yet ~33% +67.0 (n=1)
Classically starting at 3-4 weeks and improving for another 8-12
Did you experience this?
How often have you seen this?
How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
Delayed ejaculation no reports yet ~80% +0.0 (n=1)
Did you experience this?
How often have you seen this?
How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
Mood enhancement no reports yet ~5% +67.0 (n=1)
Did you experience this?
How often have you seen this?
How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
Nausea 100% -50.0 (n=2) ~33% -33.0 (n=1)
Common, often improves over 1-2 weeks.
Did you experience this?
How often have you seen this?
How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
Sexual dysfunction 100% -83.5 (n=2) — -67.0 (n=1)
Frequent; can persist long-term.
Did you experience this?
How often have you seen this?
How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
Relevant anecdote
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Relevant Literature
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Summary
Classes
SSRI, Anxiolytic, Antidepressant
Common uses
- Premature ejaculation2.1n=2
- Anxiety disorders broadly1.5n=2
- Panic disorder1.5n=2
- Depressive disorders1.1n=1
- Embarrassment0.5n=3
Pharmacy
Starting dose
10 mg
Preparations
10 mg, 20 mg, 40 mg caps
Pharmacology
Routes
Oral
Duration
Very long
Half-life
1-4 days (7-15 days for norfluoxetine)
Bioavailability
70-90% (Oral)
Pregnancy
Legal status
Rx-only
Purported mechanism
TrkB/BDNF Fluoxetine is a selective serotonin reuptake inhibitor.+1