Dexmethylphenidate: Difference between revisions
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MDElliottMD (talk | contribs) Pharmacopedia: remove contraindications parameter |
MDElliottMD (talk | contribs) Pharmacopedia: add <pharmaInteractions/> |
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Like racemic methylphenidate, '''few CYP-mediated interactions''' due to CES1-dominated metabolism. | Like racemic methylphenidate, '''few CYP-mediated interactions''' due to CES1-dominated metabolism. | ||
<pharmaInteractions/> | |||
| pregnancy_details = Category C. Crosses the placenta. Reproductive data limited and largely extrapolated from racemic methylphenidate; overall not clearly teratogenic but cohort studies suggest a small increase in cardiac malformations. Third-trimester exposure can produce transient neonatal withdrawal. Risk-benefit decision; many patients defer ADHD treatment during pregnancy. Excreted in breast milk in low amounts; breastfeeding generally compatible at therapeutic doses with infant monitoring. | | pregnancy_details = Category C. Crosses the placenta. Reproductive data limited and largely extrapolated from racemic methylphenidate; overall not clearly teratogenic but cohort studies suggest a small increase in cardiac malformations. Third-trimester exposure can produce transient neonatal withdrawal. Risk-benefit decision; many patients defer ADHD treatment during pregnancy. Excreted in breast milk in low amounts; breastfeeding generally compatible at therapeutic doses with infant monitoring. | ||
| monitoring = * Baseline: cardiovascular history (including family history of sudden cardiac death), blood pressure, heart rate, weight/height, mental health history, history of tics or substance use | | monitoring = * Baseline: cardiovascular history (including family history of sudden cardiac death), blood pressure, heart rate, weight/height, mental health history, history of tics or substance use | ||