Mixed amphetamine salts: Difference between revisions

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 If too long acting (e.g. disrupting sleep): switch to IR entirely (again at half the XR dose).
 </titration>
-| effects           = ==== Therapeutic ====
+| effects           =
 * <effect slug="attention" label="Attention and focus" author="MDElliottMD">Improved attention, executive function, and working memory.</effect>
 * <effect slug="reduced-impulsivity" label="Reduced impulsivity and hyperactivity" author="MDElliottMD"/>
@@ Line 43: / Line 43: @@
 * <effect slug="motivation" label="Motivation and drive" author="MDElliottMD"/>
 * <effect slug="euphoria" label="Mild euphoria" author="MDElliottMD"/>
+* <effect slug="decreased-appetite" label="Decreased appetite/Anorexia" author="MDElliottMD"></effect>
-==== Common ====
-* <effect slug="decreased-appetite" label="Decreased appetite" author="MDElliottMD">Often dose-limiting; may produce weight loss over time.</effect>
-* <effect slug="insomnia" label="Insomnia" author="MDElliottMD">Especially with late-afternoon dosing.</effect>
 * <effect slug="dry-mouth" label="Dry mouth" author="MDElliottMD"/>
+* <effect slug="hr-bp-elevation" label="Elevated heart rate / blood pressure" author="MDElliottMD"/>
+* <effect slug="bruxism" label="Jaw clenching / bruxism" author="MDElliottMD"/>
+* <effect slug="dry-mouth" label="Dry mouth" author="MDElliottMD"/>
+* <effect slug="insomnia" label="Insomnia" author="MDElliottMD">(with proper am dosing)</effect>
 * <effect slug="irritability" label="Irritability" author="MDElliottMD"/>
 * <effect slug="anxiety" label="Anxiety" author="MDElliottMD"/>
-* <effect slug="hr-bp-elevation" label="Elevated heart rate / blood pressure" author="MDElliottMD">Usually mild but dose-dependent.</effect>
 * <effect slug="headache" label="Headache" author="MDElliottMD"/>
-* <effect slug="bruxism" label="Jaw clenching / bruxism" author="MDElliottMD">May produce TMJ symptoms over time.</effect>
 * <effect slug="weight-loss" label="Weight loss" author="MDElliottMD"/>
-==== Cardiovascular ====
 * <effect slug="palpitations" label="Palpitations" author="MDElliottMD"/>
-* <effect slug="cardiac-event" label="Serious cardiac event" author="MDElliottMD">Rare reports of sudden cardiac death in patients with structural heart disease (FDA warning).</effect>
+* <effect slug="stereotypies" label="Stereotyped behaviors" author="MDElliottMD">Repetitive movements, e.g. skin picking, muscle twitches, tics</effect>
+* <effect slug="cardiac-event" label="Serious cardiac event" author="MDElliottMD"></effect>
-==== Psychiatric ====
 * <effect slug="agitation" label="Agitation" author="MDElliottMD"/>
-* <effect slug="psychosis" label="Psychosis" author="MDElliottMD">Rare; higher risk in patients with bipolar predisposition.</effect>
+* <effect slug="psychosis" label="Psychosis" author="MDElliottMD"></effect>
-* <effect slug="mania" label="Mania" author="MDElliottMD">Rare; higher risk in patients with bipolar predisposition.</effect>
+* <effect slug="mania" label="Mania" author="MDElliottMD"></effect>
+* <effect slug="dependence" label="Dependence / misuse" author="MDElliottMD"></effect>
-==== Other adverse ====
+* <effect slug="tolerance" label="Tolerance" author="MDElliottMD"></effect>
-* <effect slug="dependence" label="Dependence / misuse" author="MDElliottMD">Schedule II controlled substance; high abuse liability, particularly when crushed, insufflated, or injected.</effect>
+* <effect slug="growth-suppression" label="Growth suppression" author="MDElliottMD">(well documented effect with chronic use in children)</effect>
-* <effect slug="tolerance" label="Tolerance" author="MDElliottMD">To therapeutic effects, with chronic high-dose use.</effect>
+* <effect slug="serotonin-syndrome" label="Serotonin syndrome" author="MDElliottMD">Especially in combination with MAOIs</effect>
-* <effect slug="growth-suppression" label="Growth suppression" author="MDElliottMD">Modest reduction in height/weight velocity in chronically-treated children.</effect>
-* <effect slug="serotonin-syndrome" label="Serotonin syndrome" author="MDElliottMD">Especially in combination with serotonergic agents or MAOIs.</effect>
-* <effect slug="stereotypies" label="Stereotyped behaviors" author="MDElliottMD">Skin-picking, repetitive movements at higher doses.</effect>
 * <effect slug="vasculopathy" label="Peripheral vasculopathy" author="MDElliottMD">Raynaud-like phenomenon, rare digital ischemia.</effect>
-* <effect slug="seizure" label="Lowered seizure threshold" author="MDElliottMD">Caution in epilepsy.</effect>
+* <effect slug="seizure" label="Seizure/Epileptic fit" author="MDElliottMD"></effect>
 * <effect slug="hyperthermia" label="Hyperthermia" author="MDElliottMD">Risk in hot environments or with vigorous exercise.</effect>
-* <effect slug="withdrawal" label="Withdrawal / &quot;crash&quot;" author="MDElliottMD">Fatigue, depression, hypersomnia, increased appetite on abrupt discontinuation.</effect>
+* <effect slug="withdrawal" label="Withdrawal/Discontinuation Syndrome" author="MDElliottMD">Low motivation, low mood, hypersomnia, increased appetite on abrupt discontinuation.</effect>
 | contraindications = * Hypersensitivity to amphetamines
 * Concurrent MAOI use, or within 14 days of MAOI discontinuation

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