Caffeine: Difference between revisions
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| quote = 1,3,7-trimethylxanthine — the alkaloid the coffee leaf shares with the tea leaf and the cocoa pod and the kola nut and the maté and the guaraná. The world's most-consumed psychoactive molecule, the one we forget is psychoactive because we have built our days around it. Caffeine is the conversation that civilization has stopped noticing it is having. | |||
| volume = Dynamis | |||
| voice = curated paraphrase — replace with verbatim passage | |||
}} | |||
[[Category:Stimulants & Wake-Promoting Agents]] | [[Category:Stimulants & Wake-Promoting Agents]] | ||
[[Category:Xanthines]] | [[Category:Xanthines]] | ||
[[Category:Psychostimulants]] | [[Category:Psychostimulants]] | ||
Revision as of 21:43, 15 May 2026
Xanthine, Stimulant
Caffeine
Experience
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Problems
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+ Add a problemTitration strategies
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Effects
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Interactions
Pharmacogenomic + mechanism interactions
Pharmacokinetic mechanismSubstrate / metabolism relationships from primary literature
FDA Drug Interactions Table: sensitive index substrate of CYP1A2.
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Clinical relevance: does this interaction matter in practice?trivialcritical
Mechanism description, if it needs work:
Is this row worth surfacing?
Your own experience with this combination:
Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
Inferred from pharmacokinetic dataMaterialised by the inference engine; provenance shown per row
Fluvoxamine inhibits CYP1A2 (inhibitor_strong, intensity 90); Caffeine is a substrate_major of CYP1A2 (intensity 80). Derived: Caffeine exposure raised.
Inferred via Enzyme:CYP1A2 (exposure raised)
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Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
Mechanism description, if it needs work:
Is this row worth surfacing?
Your own experience with this combination:
Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
Patient experience
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Relevant anecdote
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Relevant Literature
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Summary
Classes
Xanthine, Stimulant
Pharmacy
Pharmacology
Purported mechanism
Adenosine receptor antagonist
“Pendell's corner
1,3,7-trimethylxanthine — the alkaloid the coffee leaf shares with the tea leaf and the cocoa pod and the kola nut and the maté and the guaraná. The world's most-consumed psychoactive molecule, the one we forget is psychoactive because we have built our days around it. Caffeine is the conversation that civilization has stopped noticing it is having.
— Dale Pendell, Pharmako/Dynamis
curated paraphrase — replace with verbatim passage
curated paraphrase — replace with verbatim passage