Propranolol: Difference between revisions
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MDElliottMD (talk | contribs) Create Propranolol scaffold |
MDElliottMD (talk | contribs) Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved. |
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| legal = Rx-only in US | | legal = Rx-only in US | ||
| mechanism = Non-selective competitive antagonist at β1 and β2 adrenergic receptors. Lipophilic; significant blood–brain barrier penetration, accounting for its CNS effects. | | mechanism = Non-selective competitive antagonist at β1 and β2 adrenergic receptors. Lipophilic; significant blood–brain barrier penetration, accounting for its CNS effects. | ||
| intro = Propranolol was the first clinically successful beta blocker, introduced in 1964 by James Black. It is non-selective and lipophilic | | intro = Propranolol was the first clinically successful beta blocker, introduced in 1964 by James Black. It is non-selective and lipophilic, it crosses the blood–brain barrier readily, which makes it uniquely useful for conditions with a CNS component (performance anxiety, akathisia, essential tremor, migraine prophylaxis) but also accounts for CNS side effects (vivid dreams, fatigue, depression). | ||
| indications = | | indications = | ||
| dosing = | | dosing = | ||
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| pregnancy_details = | | pregnancy_details = | ||
| monitoring = Heart rate, blood pressure | | monitoring = Heart rate, blood pressure | ||
| counseling = Do not stop abruptly | | counseling = Do not stop abruptly, taper to avoid rebound tachycardia, hypertension, or angina. Use with caution in asthma/COPD. May mask hypoglycemia symptoms in diabetics. | ||
| anecdotes = | | anecdotes = | ||
| seealso = [[Metoprolol]], [[Bisoprolol]], [[Nebivolol]] | | seealso = [[Metoprolol]], [[Bisoprolol]], [[Nebivolol]] | ||