Onabotulinumtoxin A: Difference between revisions
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| classes = Neurotoxin, neuromuscular blocker (presynaptic) | | classes = Neurotoxin, neuromuscular blocker (presynaptic) | ||
| mechanism = Cleaves SNAP-25 protein in presynaptic motor and autonomic nerve terminals, blocking acetylcholine release; in chronic migraine, hypothesized to inhibit peripheral sensitization of trigeminovascular nociceptors | | mechanism = Cleaves SNAP-25 protein in presynaptic motor and autonomic nerve terminals, blocking acetylcholine release; in chronic migraine, hypothesized to inhibit peripheral sensitization of trigeminovascular nociceptors | ||
| uses = Chronic migraine (≥15 headache days/month), cervical dystonia, blepharospasm, hyperhidrosis, overactive bladder, urinary incontinence, strabismus, spasticity, cosmetic | | uses = Chronic migraine (≥15 headache days/month), cervical dystonia, blepharospasm, hyperhidrosis, overactive bladder, urinary incontinence, strabismus, spasticity, cosmetic problems | ||
| starting_dose = Chronic migraine (PREEMPT protocol): 155 units divided across 31 sites in 7 head/neck muscle groups every 12 weeks | | starting_dose = Chronic migraine (PREEMPT protocol): 155 units divided across 31 sites in 7 head/neck muscle groups every 12 weeks | ||
| preparations = 50, 100, or 200 unit vials of lyophilized powder for reconstitution | | preparations = 50, 100, or 200 unit vials of lyophilized powder for reconstitution | ||
| fda_max = 195 units/treatment for chronic migraine; max varies by | | fda_max = 195 units/treatment for chronic migraine; max varies by problem | ||
| routes = Intramuscular (PREEMPT injections for migraine) | | routes = Intramuscular (PREEMPT injections for migraine) | ||
| onset = 1–2 weeks for muscle effects; preventive migraine benefit accrues over 12-week cycles | | onset = 1–2 weeks for muscle effects; preventive migraine benefit accrues over 12-week cycles | ||