Buprenorphine/Naloxone: Difference between revisions
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Terminology sweep (site-wide): drug/medication → medicine |
Terminology: medicine → med (shorter form per user preference) |
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| legal = Schedule III in US; X-waiver no longer required (as of 2023) | | legal = Schedule III in US; X-waiver no longer required (as of 2023) | ||
| mechanism = Buprenorphine: high-affinity partial agonist at the μ-opioid receptor with ceiling effect on respiratory depression. Naloxone: abuse-deterrent — inactive SL but precipitates withdrawal if injected. | | mechanism = Buprenorphine: high-affinity partial agonist at the μ-opioid receptor with ceiling effect on respiratory depression. Naloxone: abuse-deterrent — inactive SL but precipitates withdrawal if injected. | ||
| intro = Buprenorphine/naloxone (most widely known as Suboxone) is one of the two pillars of | | intro = Buprenorphine/naloxone (most widely known as Suboxone) is one of the two pillars of med-assisted treatment for opioid use disorder. The partial-agonist nature of buprenorphine gives it a ceiling effect on respiratory depression — far safer than full agonists like methadone. The naloxone is essentially inert SL; it exists as an injection deterrent. See [[Buprenorphine]] for the pharmacology of the active component. | ||
| indications = | | indications = | ||
| dosing = | | dosing = | ||