Testosterone: Difference between revisions
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MDElliottMD (talk | contribs) Sweep: "indications" -> "problems" sitewide terminology update (preserves MedTemplate param name) |
MDElliottMD (talk | contribs) Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved. |
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| halflife = Highly variable by formulation; native T is hours | | halflife = Highly variable by formulation; native T is hours | ||
| bioavailability = Oral non-undecanoate has essentially zero bioavailability (hepatic first-pass) | | bioavailability = Oral non-undecanoate has essentially zero bioavailability (hepatic first-pass) | ||
| pregnancy = Category X | | pregnancy = Category X, contraindicated; teratogenic (virilization of female fetus) | ||
| legal = Schedule III (DEA, US) | | legal = Schedule III (DEA, US) | ||
| mechanism = Endogenous androgen binding to androgen receptors; mediates male secondary sex characteristics, anabolism, libido, erythropoiesis, and CNS effects on mood/energy/aggression. Aromatized peripherally to estradiol; reduced to DHT. | | mechanism = Endogenous androgen binding to androgen receptors; mediates male secondary sex characteristics, anabolism, libido, erythropoiesis, and CNS effects on mood/energy/aggression. Aromatized peripherally to estradiol; reduced to DHT. | ||
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| pregnancy_details = Category X. Women of reproductive potential exposed via transdermal partner contact must wash immediately. | | pregnancy_details = Category X. Women of reproductive potential exposed via transdermal partner contact must wash immediately. | ||
| monitoring = Total/free T (timed); H/H (polycythemia); PSA; lipids; LFTs (oral); sleep apnea screen. | | monitoring = Total/free T (timed); H/H (polycythemia); PSA; lipids; LFTs (oral); sleep apnea screen. | ||
| counseling = Avoid skin-to-skin contact with women/children for several hours after gel application. Erythrocytosis is common | | counseling = Avoid skin-to-skin contact with women/children for several hours after gel application. Erythrocytosis is common, monitor hematocrit. Suppresses endogenous production and impairs fertility, discuss sperm banking in patients who may want children. | ||
| anecdotes = | | anecdotes = | ||
| seealso = [[Flibanserin]] | | seealso = [[Flibanserin]] | ||