Sertraline: Difference between revisions
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MDElliottMD (talk | contribs) Sertraline: full prescribing-guide page. History-first intro and History (Pfizer discovery 1977-1983, Koe and Welch, FDA approval 1991, the PANDA trial), pharmacokinetics, interactions, dosing, pregnancy. Clinically reviewed by pharmacist-claude; filed Pharmaceutical |
MDElliottMD (talk | contribs) Sertraline: drop the weight-neutral effect entry (a descriptor, not a ratable patient effect, per Mark); tremor effect now registered so the effects list renders complete |
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* <effect ref="bruxism" author="MDElliottMD">Recognized association with SSRIs broadly.</effect> | * <effect ref="bruxism" author="MDElliottMD">Recognized association with SSRIs broadly.</effect> | ||
* <effect ref="restless-legs" author="MDElliottMD"/> | * <effect ref="restless-legs" author="MDElliottMD"/> | ||
| pk_absorption = Oral bioavailability is not precisely characterized in humans (intravenous sertraline has not been administered for absolute bioavailability measurement). Absorption is essentially complete, with extensive first-pass metabolism limiting systemic availability. Peak plasma concentrations occur between 4.5 and 8.4 hours post-dose. Concomitant food modestly increases peak plasma levels and total exposure. Steady-state is reached within approximately one week of continuous dosing.<ref name="zoloft-label">U.S. Food and Drug Administration. Zoloft (sertraline hydrochloride) prescribing information. NDA 019839.</ref> | | pk_absorption = Oral bioavailability is not precisely characterized in humans (intravenous sertraline has not been administered for absolute bioavailability measurement). Absorption is essentially complete, with extensive first-pass metabolism limiting systemic availability. Peak plasma concentrations occur between 4.5 and 8.4 hours post-dose. Concomitant food modestly increases peak plasma levels and total exposure. Steady-state is reached within approximately one week of continuous dosing.<ref name="zoloft-label">U.S. Food and Drug Administration. Zoloft (sertraline hydrochloride) prescribing information. NDA 019839.</ref> | ||