Cyclobenzaprine: Difference between revisions
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MDElliottMD (talk | contribs) Tier 1 taxonomy consolidation: removed redundant Category:Muscle_Relaxants (canonical already present) |
MDElliottMD (talk | contribs) parser-claude: Cyclobenzaprine MedTemplate refill, Top 300 stub upgrade |
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{{MedTemplate | {{MedTemplate | ||
| generic | | generic = Cyclobenzaprine | ||
| brand | | brand = Flexeril (IR; brand discontinued in US, generic widely available), Amrix (ER) | ||
| structure | | structure = | ||
| classes | | classes = [[:Category:Skeletal muscle relaxants|Skeletal muscle relaxant (centrally-acting)]], [[:Category:Tricyclic-related compounds|Tricyclic-related compound]] | ||
| | | uses = <vote slug="acute-muscle-spasm-use">Short-term relief of muscle spasm from acute musculoskeletal conditions (FDA; ≤2-3 weeks)</vote>, <vote slug="fibromyalgia-low-dose-use">Fibromyalgia (off-label, low-dose evening)</vote>, <vote slug="insomnia-cyclobenzaprine-use">Insomnia adjunct (off-label, low-dose)</vote> | ||
| | | starting_dose = IR 5 mg PO TID; titrate to 10 mg TID if needed. Amrix ER 15 mg PO once daily. Off-label insomnia / fibromyalgia: 5-10 mg PO at bedtime | ||
| | | preparations = IR tablets 5, 7.5, 10 mg; Amrix ER capsules 15, 30 mg | ||
| | | fda_max = 30 mg/day (IR or ER) | ||
| | | pill_id = | ||
| routes | | routes = Oral | ||
| onset | | onset = ~1 hour | ||
| duration | | duration = 12-24 hours (IR); 24 hours (Amrix ER) | ||
| halflife | | halflife = 18 hours (IR); 32-33 hours (ER)<ref name="flexeril-label">FDA Prescribing Information, Flexeril (cyclobenzaprine hydrochloride), Merck/various, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017821s048lbl.pdf</ref> | ||
| bioavailability = ~33-55% (IR); reduced by food<ref name="flexeril-label" /> | |||
| pregnancy = Limited human data.{{citation needed}} | |||
| legal = [[USLegal:Prescription only|Rx-only]] in US. Not a controlled substance, distinguishing it from the carisoprodol alternative for muscle spasm<ref name="flexeril-label" /> | |||
| | | mechanism = <vote slug="cyclobenzaprine-mech-claim">Structurally a tricyclic compound closely related to amitriptyline but FDA-approved as a muscle relaxant rather than an antidepressant. Centrally-acting via brainstem and supraspinal sites, reducing tonic somatic motor activity through noradrenergic descending pathways; the spinal cord is not the primary site of action. Substantial anticholinergic, H1 antihistaminergic, and α1-adrenergic antagonist activity accounts for sedation, dry mouth, and orthostatic adverse effects.</vote> '''Serotonin syndrome''' risk applies through the tricyclic-class identity when combined with SSRIs, SNRIs, MAOIs, tramadol, or other serotonergic agents. FDA labeling restricts to short-term use (≤2-3 weeks); evidence for prolonged use is limited<ref name="flexeril-label" />. | ||
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[[Category: | == References == | ||
<references /> | |||
[[Category:Skeletal muscle relaxants]] | |||
[[Category:Tricyclic-related compounds]] | |||