2C-B: Difference between revisions
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MDElliottMD (talk | contribs) 2C-B: link the remaining serotonergic-list terms (SNRIs, lithium, dextromethorphan) per pharmacist-claude verification; all 6 now linked |
MDElliottMD (talk | contribs) 2C-B harm-reduction: clinical correction (pharmacist-claude) - lithium moved out of the serotonin-syndrome list into its own sentence (lithium + psychedelic risk is seizures/severe reactions, not serotonin syndrome) |
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<titration slug="harm-reduction" author="MDElliottMD" title="Harm reduction considerations"> | <titration slug="harm-reduction" author="MDElliottMD" title="Harm reduction considerations"> | ||
2C-B is a Schedule I controlled substance in the United States with no approved medical use and no legal supply chain that guarantees product identity or purity; in modern markets it is frequently misrepresented as MDMA or substituted with other compounds, including the structurally similar but pharmacologically distinct [[DOB]]. Onset after oral administration is typically 45-75 minutes; the long onset combined with the steep dose-response curve drives a common harm pattern in which inexperienced users redose during the onset window and overshoot the intended dose. Combinations with serotonergic medicines ([[:Category:Selective Serotonin Reuptake Inhibitors (SSRIs)|SSRIs]], [[:Category:Serotonin–Norepinephrine Reuptake Inhibitors (SNRIs)|SNRIs]], [[:Category:Monoamine Oxidase Inhibitors (MAOIs)|MAOIs]], [[Tramadol|tramadol | 2C-B is a Schedule I controlled substance in the United States with no approved medical use and no legal supply chain that guarantees product identity or purity; in modern markets it is frequently misrepresented as MDMA or substituted with other compounds, including the structurally similar but pharmacologically distinct [[DOB]]. Onset after oral administration is typically 45-75 minutes; the long onset combined with the steep dose-response curve drives a common harm pattern in which inexperienced users redose during the onset window and overshoot the intended dose. Combinations with serotonergic medicines ([[:Category:Selective Serotonin Reuptake Inhibitors (SSRIs)|SSRIs]], [[:Category:Serotonin–Norepinephrine Reuptake Inhibitors (SNRIs)|SNRIs]], [[:Category:Monoamine Oxidase Inhibitors (MAOIs)|MAOIs]], [[Tramadol|tramadol]], [[Dextromethorphan|dextromethorphan]]) carry [[Serotonin syndrome|serotonin syndrome]] risk and should be avoided. [[Lithium]] is a separate concern: combined with psychedelics it is associated with a markedly increased risk of seizures and severe adverse reactions, and should likewise be avoided. Combinations with stimulants increase cardiovascular load. The general harm-reduction principles for psychedelic experiences (set, setting, sober companion, advance arrangement of supportive contacts) apply to 2C-B as they do to other 5-HT2A agonists. | ||
</titration> | </titration> | ||