DMT: Difference between revisions
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MDElliottMD (talk | contribs) DMT: add 77-effect subjective profile (parser-claude handoff; PsychonautWiki CC BY-SA, source Mark-approved); full internal-linking pass on the prose per the linking rule |
MDElliottMD (talk | contribs) Link legal-status field to the USLegal: namespace |
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| bioavailability = | | bioavailability = | ||
| pregnancy = | | pregnancy = | ||
| legal = Schedule I (United States) | | legal = [[USLegal:DEA Schedule I|Schedule I]] (United States) | ||
| mechanism = 5-HT2A partial agonist; sigma-1 agonist | | mechanism = 5-HT2A partial agonist; sigma-1 agonist | ||
| intro = The earliest record of human use of DMT-bearing medicines comes from the Amazon and the Orinoco, where indigenous peoples have for centuries prepared visionary preparations from plants that contain the molecule. The most widespread of these is [[Ayahuasca|ayahuasca]], a brew of the [[Banisteriopsis caapi]] vine cooked together with the leaves of [[Psychotria viridis]] or related DMT-bearing companions. The vine contains [[Harmine|harmine]] and [[Harmaline|harmaline]], which inhibit [[Monoamine oxidase|monoamine oxidase]] and allow orally administered DMT, which would otherwise be destroyed in the gut, to reach the brain. The pairing is the technical accomplishment that defines the tradition. Whether indigenous knowledge of the pairing predates European contact in its present form is debated by ethnobotanists, but the brew was encountered by missionaries in the upper Amazon in the 19th century and entered ethnographic literature through [[Richard Spruce]]'s botanical work in the 1850s and, later, through [[Richard Evans Schultes]] at the Harvard Botanical Museum.<ref name="schultes1969">Schultes RE. Hallucinogens of plant origin. Science. 1969;163(3864):245-254. PMID: 4883616.</ref> | | intro = The earliest record of human use of DMT-bearing medicines comes from the Amazon and the Orinoco, where indigenous peoples have for centuries prepared visionary preparations from plants that contain the molecule. The most widespread of these is [[Ayahuasca|ayahuasca]], a brew of the [[Banisteriopsis caapi]] vine cooked together with the leaves of [[Psychotria viridis]] or related DMT-bearing companions. The vine contains [[Harmine|harmine]] and [[Harmaline|harmaline]], which inhibit [[Monoamine oxidase|monoamine oxidase]] and allow orally administered DMT, which would otherwise be destroyed in the gut, to reach the brain. The pairing is the technical accomplishment that defines the tradition. Whether indigenous knowledge of the pairing predates European contact in its present form is debated by ethnobotanists, but the brew was encountered by missionaries in the upper Amazon in the 19th century and entered ethnographic literature through [[Richard Spruce]]'s botanical work in the 1850s and, later, through [[Richard Evans Schultes]] at the Harvard Botanical Museum.<ref name="schultes1969">Schultes RE. Hallucinogens of plant origin. Science. 1969;163(3864):245-254. PMID: 4883616.</ref> | ||