2C-B: Difference between revisions
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MDElliottMD (talk | contribs) 2C-B final link addendum (web-claude, consolidated): merge new links onto the citation-corrected page (5-HT2A/2C/2B receptors, monoamine transporter, Schedule I, Controlled Substances Act, Convention on Psychotropic Substances, Medicines Control Council, Ann Shulgin, Empathogens); psychostimulants house-term fix; propagate the lithium clinical correction into the interactions field |
MDElliottMD (talk | contribs) Repoint CYP2D6/CYP3A4 links to the new Enzyme: namespace |
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* '''Lithium: seizure and severe-reaction risk.''' Lithium combined with psychedelics including 2C-B is associated with a markedly increased risk of seizures and severe adverse reactions; the mechanism is distinct from serotonin syndrome. Avoid combination. | * '''Lithium: seizure and severe-reaction risk.''' Lithium combined with psychedelics including 2C-B is associated with a markedly increased risk of seizures and severe adverse reactions; the mechanism is distinct from serotonin syndrome. Avoid combination. | ||
* '''Psychostimulants: additive cardiovascular load.''' 2C-B itself produces modest sympathomimetic effects (elevated heart rate, mild blood pressure increase); concurrent psychostimulants compound the cardiovascular burden. | * '''Psychostimulants: additive cardiovascular load.''' 2C-B itself produces modest sympathomimetic effects (elevated heart rate, mild blood pressure increase); concurrent psychostimulants compound the cardiovascular burden. | ||
* '''CYP interactions: not well characterized.''' Human metabolism of 2C-B has not been comprehensively studied. In vitro work suggests [[ | * '''CYP interactions: not well characterized.''' Human metabolism of 2C-B has not been comprehensively studied. In vitro work suggests [[Enzyme:CYP2D6|CYP2D6]] and [[Enzyme:CYP3A4|CYP3A4]] involvement; strong inhibitors of these enzymes may increase 2C-B exposure. | ||
| pregnancy_details = Not characterized. 2C-B has not been studied in human pregnancy; no preclinical reproductive toxicology data are available in the public literature. The compound's Schedule I status precludes systematic study under conventional regulatory frameworks. Avoid in pregnancy on first-principles grounds. | | pregnancy_details = Not characterized. 2C-B has not been studied in human pregnancy; no preclinical reproductive toxicology data are available in the public literature. The compound's Schedule I status precludes systematic study under conventional regulatory frameworks. Avoid in pregnancy on first-principles grounds. | ||