Enzyme:CYP2E1: Difference between revisions
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MDElliottMD (talk | contribs) m MDElliottMD moved page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP2E1 to Enzyme:CYP2E1: Migrate enzyme entity pages from Pharmacogenomics sandbox to the new Enzyme: namespace |
MDElliottMD (talk | contribs) Add scope="col" to the data-table column headers for screen-reader association (ADA audit M5; designer-claude 2026-05-22) |
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{| class="wikitable sortable mw-collapsible mw-collapsed" style="width:100%;" | {| class="wikitable sortable mw-collapsible mw-collapsed" style="width:100%;" | ||
|+ style="white-space:nowrap; text-align:left;" | near-complete CYP2E1 medicine-substrate table (click to expand) | |+ style="white-space:nowrap; text-align:left;" | near-complete CYP2E1 medicine-substrate table (click to expand) | ||
! Substrate !! Therapeutic class !! CYP2E1 contribution !! Clinical notes | ! scope="col" | Substrate !! scope="col" | Therapeutic class !! scope="col" | CYP2E1 contribution !! scope="col" | Clinical notes | ||
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| '''[[Acetaminophen]]''' || Analgesic / antipyretic (paracetamol) || partial (toxic route) || '''The clinically critical CYP2E1 substrate.''' At therapeutic doses acetaminophen is cleared mostly by glucuronidation and sulfation; a minor oxidative route, substantially CYP2E1-mediated, generates the hepatotoxic metabolite NAPQI. CYP2E1 induction (chronic alcohol, fasting) increases NAPQI formation. See Clinical implications. | | '''[[Acetaminophen]]''' || Analgesic / antipyretic (paracetamol) || partial (toxic route) || '''The clinically critical CYP2E1 substrate.''' At therapeutic doses acetaminophen is cleared mostly by glucuronidation and sulfation; a minor oxidative route, substantially CYP2E1-mediated, generates the hepatotoxic metabolite NAPQI. CYP2E1 induction (chronic alcohol, fasting) increases NAPQI formation. See Clinical implications. | ||