Lisinopril: Difference between revisions
| [unchecked revision] | [unchecked revision] |
MDElliottMD (talk | contribs) parser-claude batch MedTemplate pre-fill, Top 300 #4 |
MDElliottMD (talk | contribs) home-claude category backfill (parser-claude gap closure) |
||
| Line 21: | Line 21: | ||
== References == | == References == | ||
<references /> | <references /> | ||
[[Category:ACE inhibitors]] | |||
[[Category:Antihypertensives]] | |||
Latest revision as of 10:43, 23 May 2026
Lisinopril
Zestril, Prinivil, Qbrelis
Experience
No personal reports yet
No clinical reports yet
Log in to add your own experience.
Problems
No problems yet. Be the first to suggest one.
+ Add a problemTitration strategies
No titration strategies yet. Be the first to suggest one.
Effects
No effects listed yet. Be the first to suggest one.
Relevant anecdote
No anecdotes yet. Share a relevant one.
Relevant Literature
No literature entries yet.
Log in to submit relevant literature.
Summary
Classes
Common uses
Hypertension0, Heart failure0, Post-myocardial infarction0, Diabetic nephropathy0
Pharmacy
Starting dose
5-10 mg PO once daily (2.5 mg in heart failure, hyponatremia, or volume depletion)
Preparations
2.5, 5, 10, 20, 30, 40 mg tablets; 1 mg/mL oral solution
US FDA Max
80 mg/d
Pharmacology
Routes
Oral
Onset
BP lowering within 1 hour; max effect at 6 hours
Duration
24 hours
Half-life
~12 hours (effective); terminal half-life is biphasic[1]
Bioavailability
~25% (oral; food does not affect absorption)[1]
Pregnancy
Contraindicated in pregnancy (all trimesters); fetal renal injury, oligohydramnios, skull hypoplasia, hypotension. Stop on detection[1]
Legal status
Rx-only in US
Purported mechanism
Lisinopril is a long-acting ACE inhibitor that blocks conversion of angiotensin I to angiotensin II, reducing vasoconstriction, aldosterone secretion, and renal sodium retention.0 Also raises bradykinin, contributing to vasodilation and the characteristic dry cough. Renally cleared, unmetabolized; dose-adjust by eGFR[1].
References
- ↑ 1.0 1.1 1.2 1.3 FDA Prescribing Information, Zestril (lisinopril), AstraZeneca, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019777s056lbl.pdf