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Oxcarbazepine: Difference between revisions

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[[Category:Mood_Stabilizers]]
[[Category:Mood stabilizers]]
[[Category:Sodium channel blockers]]
[[Category:Sodium channel blockers]]
[[Category:Antiepileptics]]
[[Category:Antiepileptics]]
[[Category:Mood stabilizers]]
[[Category:Mood stabilizers]]

Revision as of 05:05, 23 May 2026

Mood Stabilizer, Anticonvulsant
Oxcarbazepine
Trileptal

Experience

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Problems

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Titration strategies

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Effects

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Interactions

Pharmacogenomic + mechanism interactions2 edges
Pharmacogenomic guideline recommendationsCPIC and Dutch Pharmacogenetics Working Group clinical guidelines
Variant:hla-b 1502 pos contraindication CPIC A 90 / 100
CPIC rec 8094683 [Strong]: If patient is oxcarbazepine-naïve, do not use oxcarbazepine. CPIC pair-level A (HLA-A, HLA-B and Carbamazepine and Oxcarbazepine) [PMID 29392710]
Variant:hla-b 1502 pos risk hypersensitivity CPIC A 20 / 100
CPIC rec 8094685 [Optional]: The latency period for drug-induced SJS/TEN is short with continuous dosing and adherence to therapy (~4-28 days), and cases usually occur within three months of dosing; therefore, if the patient has previously used oxcarbazepine consistently for longer than three months without incidence of cutaneous adverse reactions, cautiously consider use of oxcarbazepine in the future. CPIC pair-level A (HLA-A, HLA-B and Carbamazepine and Oxcarbazepine) [PMID 29392710]

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Relevant Literature

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Summary
Classes
Mood Stabilizer, Anticonvulsant
Common uses
Pharmacy
Pharmacology
Purported mechanism
Sodium channel blocker