Quetiapine: Difference between revisions
From Pharmacopedia
More actions
| [unchecked revision] | [unchecked revision] |
Sentence-case category link per house style (Mood_Stabilizers → Mood_stabilizers) |
MDElliottMD (talk | contribs) parser-claude: replace retired FDA Category C label and broken LactMed ref on Quetiapine; one-line summary consistent with pregnancy_details prose |
||
| Line 21: | Line 21: | ||
| halflife = ~6 h (parent compound, immediate-release); ~9-12 h (active metabolite N-desalkylquetiapine, also called norquetiapine) | | halflife = ~6 h (parent compound, immediate-release); ~9-12 h (active metabolite N-desalkylquetiapine, also called norquetiapine) | ||
| bioavailability = Tablet ~100% relative to oral solution; extensive first-pass metabolism | | bioavailability = Tablet ~100% relative to oral solution; extensive first-pass metabolism | ||
| pregnancy = | | pregnancy = Pregnancy categories were retired by FDA in 2015. Quetiapine has reassuring active-comparator cohort data without consistent teratogenic signal; among the preferred neuroleptics when treatment is clinically necessary in pregnancy. See pregnancy_details for the full citation set. | ||
| legal = [[USLegal:Prescription only|Prescription only]]; not a controlled substance | | legal = [[USLegal:Prescription only|Prescription only]]; not a controlled substance | ||
| mechanism = Dopamine D2 and serotonin 5-HT2A receptor antagonist<ref name="quet-mech">S1</ref> <vote slug="atypical-claim-quet">Quetiapine acts as an antagonist at dopamine D2 and serotonin 5-HT2A receptors and has substantial activity at histaminergic, adrenergic, and other receptors that contribute to its clinical effects.</vote> | | mechanism = Dopamine D2 and serotonin 5-HT2A receptor antagonist<ref name="quet-mech">S1</ref> <vote slug="atypical-claim-quet">Quetiapine acts as an antagonist at dopamine D2 and serotonin 5-HT2A receptors and has substantial activity at histaminergic, adrenergic, and other receptors that contribute to its clinical effects.</vote> | ||