Fluoxetine: Difference between revisions
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MDElliottMD (talk | contribs) Added effect: Anorgasmia |
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* <effect ref="temporary-erectile-dysfunction" author="MDElliottMD"/> | * <effect ref="temporary-erectile-dysfunction" author="MDElliottMD"/> | ||
* <effect ref="persistent-sexual-dysfunction" author="MDElliottMD">Historically [https://pmc.ncbi.nlm.nih.gov/articles/PMC11450419/ associated with SSRIs].</effect> | * <effect ref="persistent-sexual-dysfunction" author="MDElliottMD">Historically [https://pmc.ncbi.nlm.nih.gov/articles/PMC11450419/ associated with SSRIs].</effect> | ||
<effect ref="anorgasmia" author="MDElliottMD"/> | |||
| pk_absorption = 70–90%<ref name="statpearls">https://www.ncbi.nlm.nih.gov/books/NBK459223/</ref> oral bioavailability. | | pk_absorption = 70–90%<ref name="statpearls">https://www.ncbi.nlm.nih.gov/books/NBK459223/</ref> oral bioavailability. | ||
| pk_distribution = Fluoxetine has plasma protein binding of approximately 94.5%, bound to albumin and alpha-1 glycoprotein. Fluoxetine readily crosses the blood–brain barrier, with a brain-to-plasma ratio of 2.6:1 in humans. The volume of distribution (Vd) of fluoxetine and its metabolite ranges between 20 to 42 L/kg. Some studies report that fluoxetine has the maximum volume of distribution (Vd) of any SSRI (between 14 and 100 L/kg).<ref name="statpearls"/> | | pk_distribution = Fluoxetine has plasma protein binding of approximately 94.5%, bound to albumin and alpha-1 glycoprotein. Fluoxetine readily crosses the blood–brain barrier, with a brain-to-plasma ratio of 2.6:1 in humans. The volume of distribution (Vd) of fluoxetine and its metabolite ranges between 20 to 42 L/kg. Some studies report that fluoxetine has the maximum volume of distribution (Vd) of any SSRI (between 14 and 100 L/kg).<ref name="statpearls"/> | ||