Fluoxetine: Difference between revisions
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| structure = Fluoxwhite.svg | | structure = Fluoxwhite.svg | ||
| classes = SSRI, Anxiolytic, Antidepressant | | classes = SSRI, Anxiolytic, Antidepressant | ||
| uses = Anxiety, premature ejaculation, low mood | | uses = Anxiety, premature ejaculation, low mood | ||
| | | starting_dose = 10 mg | ||
| | | preparations = 10 mg, 20 mg, 40 mg caps | ||
| atc = | | atc = | ||
| routes = Oral | | routes = Oral | ||
| Line 17: | Line 15: | ||
| pregnancy = Category C | | pregnancy = Category C | ||
| legal = Rx-only | | legal = Rx-only | ||
| mechanism = [https://pmc.ncbi.nlm.nih.gov/articles/PMC9666396/ TrkB/BDNF] <vote slug="test1">Fluoxetine is a selective serotonin reuptake inhibitor.</vote> | |||
| intro = Fluoxetine is the first of a long line of SSRIs to come. It is remarkable in its extremely long half life and relative lack of withdrawal syndrome. It can also be very useful it helping taper and terminate other SxRI medicines. | | intro = Fluoxetine is the first of a long line of SSRIs to come. It is remarkable in its extremely long half life and relative lack of withdrawal syndrome. It can also be very useful it helping taper and terminate other SxRI medicines. | ||
| pharmacology = | | pharmacology = | ||
Revision as of 22:04, 12 May 2026
SSRI, Anxiolytic, Antidepressant
Fluoxetine
Prozac
Fluoxetine is the first of a long line of SSRIs to come. It is remarkable in its extremely long half life and relative lack of withdrawal syndrome. It can also be very useful it helping taper and terminate other SxRI medicines.
Start no higher than 10 mg for first dose! Participant may increase by 10 mg every 2-12 weeks, or never increase if they are satisfied with the 10 mg effect.
2D6 - many
none
Experience
No personal reports yet
1 provider report · avg efficacy 40.0/100 · avg side-effect burden 40.0/100 · 150 patients managed total
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Problems
Anxiety disorders broadly, including panic attacks, social anxiety,
+ Add a problemTitration strategies
Discussion (0)
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Effects
Anxiolysis no reports yet ~33% +67.0 (n=1)
Classically starting at 3-4 weeks and improving for another 8-12
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Delayed ejaculation no reports yet ~80% +0.0 (n=1)
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Mood enhancement no reports yet ~5% +67.0 (n=1)
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Nausea 100% -50.0 (n=2) ~33% -33.0 (n=1)
Common, often improves over 1-2 weeks.
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Sexual dysfunction 100% -83.5 (n=2) — -67.0 (n=1)
Frequent; can persist long-term.
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Interactions
Monitoring
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Relevant Literature
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Summary
Classes
SSRI, Anxiolytic, Antidepressant
Common uses
- Premature ejaculation2.1n=2
- Anxiety disorders broadly1.5n=2
- Panic disorder1.5n=2
- Depressive disorders1.1n=1
- Embarrassment0.5n=3
Pharmacy
Starting dose
10 mg
Preparations
10 mg, 20 mg, 40 mg caps
Pharmacology
Routes
Oral
Duration
Very long
Half-life
1-4 days (7-15 days for norfluoxetine)
Bioavailability
70-90%
Pregnancy
Category C
Legal status
Rx-only
Purported mechanism
TrkB/BDNF Fluoxetine is a selective serotonin reuptake inhibitor.+1