Fluoxetine: Difference between revisions
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| starting_dose = 10 mg | | starting_dose = 10 mg | ||
| preparations = 10 mg, 20 mg, 40 mg caps | | preparations = 10 mg, 20 mg, 40 mg caps | ||
| routes = Oral | | routes = Oral | ||
| onset = | | onset = | ||
| duration = Very long | | duration = Very long | ||
| halflife = 1-4 days (7-15 days for norfluoxetine) | | halflife = 1-4 days (7-15 days for norfluoxetine) | ||
| bioavailability = 70-90% | | bioavailability = 70-90% (Oral) | ||
| pregnancy = Category C | | pregnancy = [https://www.ncbi.nlm.nih.gov/books/NBK501186/ Category C] | ||
| legal = Rx-only | | legal = Rx-only | ||
| mechanism = [https://pmc.ncbi.nlm.nih.gov/articles/PMC9666396/ TrkB/BDNF] <vote slug="test1">Fluoxetine is a selective serotonin reuptake inhibitor.</vote> | | mechanism = [https://pmc.ncbi.nlm.nih.gov/articles/PMC9666396/ TrkB/BDNF] <vote slug="test1">Fluoxetine is a selective serotonin reuptake inhibitor.</vote> | ||
| intro = Fluoxetine | | intro = Fluoxetine was the first to be released of a long line of subsequent SSRIs. It is remarkable in its extremely long half life and relative lack of withdrawal syndrome. It can also be very useful it helping taper and terminate other SxRI medicines. | ||
| pharmacokinetics = | | pharmacokinetics = | ||
| indications = Anxiety disorders broadly, including panic attacks, social anxiety, | | pharmacodynamics = | ||
| indications = Anxiety disorders broadly, including panic attacks, social anxiety, | |||
| dosing = Start no higher than 10 mg for first dose! Participant may increase by 10 mg every 2-12 weeks, or never increase if they are satisfied with the 10 mg effect.<discuss slug="titration-discussion"/> | | dosing = Start no higher than 10 mg for first dose! Participant may increase by 10 mg every 2-12 weeks, or never increase if they are satisfied with the 10 mg effect.<discuss slug="titration-discussion"/> | ||
| effects = <effect slug="anxiolysis" label="Anxiolysis">Classically starting at 3-4 weeks and improving for another 8-12</effect> | | effects = <effect slug="anxiolysis" label="Anxiolysis">Classically starting at 3-4 weeks and improving for another 8-12</effect> | ||
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</effect><effect slug="nausea" label="Nausea">Common, often improves over 1-2 weeks.</effect> | </effect><effect slug="nausea" label="Nausea">Common, often improves over 1-2 weeks.</effect> | ||
<effect slug="sexual-dysfunction" label="Sexual dysfunction">Frequent; can persist long-term.</effect> | <effect slug="sexual-dysfunction" label="Sexual dysfunction">Frequent; can persist long-term.</effect> | ||
| contraindications = | | contraindications = | ||
| interactions = | | interactions = | ||
| pregnancy_details = | | pregnancy_details = | ||
| monitoring = | | monitoring = | ||
| counseling = | | counseling = | ||
| anecdotes = | | anecdotes = | ||