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Duloxetine: Difference between revisions

From Pharmacopedia
[checked revision][checked revision]
Created page with "{{MedTemplate | generic = Duloxetine | brand = Cymbalta, Drizalma Sprinkle, Irenka, Yentreve | structure = Duloxetine.svg | classes = SNRI, Antidepressant, Anxiolytic | mechanism = Serotonin–norepinephrine reuptake inhibition (balanced) | uses = Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain | formula = C<sub>18</sub>H<sub>19</sub>NOS | routes = Oral | o..."
 
Pharmacopedia: remove contraindications parameter
Line 38: Line 38:
* '''Urinary hesitancy'''
* '''Urinary hesitancy'''
* '''Discontinuation syndrome''' — among the more pronounced of the SNRI/SSRI class; dizziness, paresthesias ("brain zaps"), irritability, nausea
* '''Discontinuation syndrome''' — among the more pronounced of the SNRI/SSRI class; dizziness, paresthesias ("brain zaps"), irritability, nausea
| contraindications = * Concurrent MAOI use (within 14 days)
* Severe hepatic impairment
* Severe renal impairment (CrCl <30 mL/min)
* Uncontrolled narrow-angle glaucoma
* Heavy alcohol use (hepatotoxicity risk)
| interactions      = * '''MAOIs''' — serotonin syndrome; contraindicated
| interactions      = * '''MAOIs''' — serotonin syndrome; contraindicated
* '''CYP1A2 inhibitors''' (ciprofloxacin, fluvoxamine, enoxacin) — substantially increase duloxetine levels; avoid combination
* '''CYP1A2 inhibitors''' (ciprofloxacin, fluvoxamine, enoxacin) — substantially increase duloxetine levels; avoid combination