Alprazolam: Difference between revisions
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MDElliottMD (talk | contribs) Pharmacopedia: remove contraindications parameter |
MDElliottMD (talk | contribs) Pharmacopedia: add <pharmaInteractions/> |
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* '''Grapefruit juice''' — modest CYP3A4 inhibition; can raise alprazolam levels with regular consumption | * '''Grapefruit juice''' — modest CYP3A4 inhibition; can raise alprazolam levels with regular consumption | ||
* '''Fluoxetine, fluvoxamine''' — increase alprazolam levels via CYP3A4 inhibition | * '''Fluoxetine, fluvoxamine''' — increase alprazolam levels via CYP3A4 inhibition | ||
<pharmaInteractions/> | |||
| pregnancy_details = Historically Category D. First-trimester benzodiazepine exposure has been associated with increased risk of cleft lip/palate in some studies, though absolute risk is small. Third-trimester or near-term use can produce '''floppy infant syndrome''' (hypotonia, hypothermia, feeding difficulty, respiratory depression) and neonatal withdrawal. Generally avoided in pregnancy unless benefits clearly outweigh risks; SSRIs are usually preferred for chronic anxiety. Excreted in breast milk — breastfeeding generally discouraged. | | pregnancy_details = Historically Category D. First-trimester benzodiazepine exposure has been associated with increased risk of cleft lip/palate in some studies, though absolute risk is small. Third-trimester or near-term use can produce '''floppy infant syndrome''' (hypotonia, hypothermia, feeding difficulty, respiratory depression) and neonatal withdrawal. Generally avoided in pregnancy unless benefits clearly outweigh risks; SSRIs are usually preferred for chronic anxiety. Excreted in breast milk — breastfeeding generally discouraged. | ||
| monitoring = * Continued need for treatment — reassess at every visit; target shortest effective duration | | monitoring = * Continued need for treatment — reassess at every visit; target shortest effective duration | ||