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Opioids bind opioid receptors — especially the µ-opioid receptor — in the nervous system; the relationship between this binding and their analgesic and other effects is addressed in [[:Category:Opioids]]. The skeletal muscle relaxants are a varied group whose mechanisms are not all well established; baclofen, for example, is understood to act at GABA receptors in the spinal cord, but the detail of its action as a muscle relaxant is described in the literature as incompletely understood.<ref name="witenko2014"/> Adjuvant analgesics — including certain antidepressants and anticonvulsants — are used mainly for neuropathic pain. | Opioids bind opioid receptors — especially the µ-opioid receptor — in the nervous system; the relationship between this binding and their analgesic and other effects is addressed in [[:Category:Opioids]]. The skeletal muscle relaxants are a varied group whose mechanisms are not all well established; baclofen, for example, is understood to act at GABA receptors in the spinal cord, but the detail of its action as a muscle relaxant is described in the literature as incompletely understood.<ref name="witenko2014"/> Adjuvant analgesics — including certain antidepressants and anticonvulsants — are used mainly for neuropathic pain. | ||
== Members == | |||
The analgesics include the [[:Category:NSAIDs]] (such as [[aspirin]], [[ibuprofen]], and [[naproxen]]), [[paracetamol]] (acetaminophen), the [[:Category:Opioids]] (such as [[morphine]], [[oxycodone]], and [[fentanyl]]), and the [[:Category:Muscle relaxants]]. Further agents are used for specific pain syndromes — including triptans, ergot derivatives, and gepants for migraine, and certain antidepressants and anticonvulsants as adjuvants for neuropathic pain. The list is not exhaustive. | |||
== Safety == | == Safety == | ||