Methamphetamine: Difference between revisions
| [pending revision] | [pending revision] |
MDElliottMD (talk | contribs) Recategorize: Stimulants & Wake-Promoting Agents -> Stimulants |
MDElliottMD (talk | contribs) Recategorize: Stimulants -> Psychostimulants |
||
| Line 63: | Line 63: | ||
[[Category: | [[Category:Psychostimulants]] | ||
[[Category:Amphetamines]] | [[Category:Amphetamines]] | ||
[[Category:Psychostimulants]] | [[Category:Psychostimulants]] | ||
[[Category:Phenethylamines]] | [[Category:Phenethylamines]] | ||
Revision as of 10:50, 17 May 2026
Psychostimulant, Amphetamine
Methamphetamine
Desoxyn
Methamphetamine is a CNS stimulant of the amphetamine class. It is FDA-approved (as Desoxyn) for attention-deficit hyperactivity disorder and short-term management of obesity. It is a Schedule II controlled substance in the United States.
+ Add a problem
Methamphetamine acts at monoaminergic terminals as a releasing agent via TAAR1 agonism, VMAT2 substrate activity, and DAT/NET reverse transport. Secondary mechanisms include weak monoamine reuptake inhibition.
Category C per Desoxyn label.
Mixed amphetamine salts, Dextroamphetamine, Lisdexamfetamine, Methylphenidate, Dexmethylphenidate, Modafinil
Experience
No personal reports yet
No clinical reports yet
Log in to add your own experience.
Problems
Obesity (short-term)— 1 don't know
Titration strategies
No titration strategies yet. Be the first to suggest one.
Effects
- Attention and focus no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Wakefulness no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Motivation and drive no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Mild euphoria no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Decreased appetite/Anorexia no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Dry mouth no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Elevated heart rate / blood pressure no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Insomnia no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Irritability no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Anxiety no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Headache no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Weight loss no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Palpitations no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Jaw clenching / bruxism no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Stereotyped behaviors no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Agitation no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Psychosis no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Mania no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Dependence / misuse no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Tolerance no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Serious cardiac event no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Seizure/Epileptic fit no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Hyperthermia no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Serotonin syndrome no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
- Withdrawal/Discontinuation Syndrome no reports yet no reports yetDid you experience this?How often have you seen this?How was it? (-100 worst, +100 best)How was it? (-100 worst, +100 best)
Pharmacokinetics
Metabolism
Hepatic metabolism includes N-demethylation to amphetamine (an active metabolite).Elimination
Urinary elimination is pH-dependent.Pharmacodynamics
Interactions
- MAOIs — contraindicated (per label)
- Acidifying agents — increase urinary clearance
- Alkalinizing agents — decrease urinary clearance
No interactions reported yet.
Pregnancy and lactation
Relevant anecdote
No anecdotes yet. Share a relevant one.
Relevant Literature
No literature entries yet.
Log in to submit relevant literature.
See also
References
Summary
Classes
Psychostimulant, Amphetamine
Common uses
Inattention0, Hyperactivity0, Obesity0
Pharmacy
Starting dose
5 mg PO
Preparations
Desoxyn 5 mg tabs
US FDA Max
25 mg/day (ADHD per Desoxyn label); 15 mg/day (obesity, short-term, per Desoxyn label)
Pharmacology
Routes
Oral (prescribed)
Pregnancy
Category C (per Desoxyn label)
Legal status
Schedule II
Purported mechanism
Monoamine releasing agent — TAAR1 agonism, VMAT2 substrate, DAT/NET reverse transport