Prazosin: Difference between revisions
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MDElliottMD (talk | contribs) Create Prazosin scaffold |
MDElliottMD (talk | contribs) Em-dash sweep: replace em-dash with comma per project rule; PendellsCorner verbatim quotes preserved. |
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| legal = Rx-only in US | | legal = Rx-only in US | ||
| mechanism = Selective alpha-1 adrenergic receptor antagonist. Lowers peripheral vascular resistance via vasodilation; in the CNS, blunts noradrenergic hyperarousal thought to drive trauma-related nightmares. | | mechanism = Selective alpha-1 adrenergic receptor antagonist. Lowers peripheral vascular resistance via vasodilation; in the CNS, blunts noradrenergic hyperarousal thought to drive trauma-related nightmares. | ||
| intro = Prazosin is best known in psychiatry as an off-label treatment for PTSD nightmares | | intro = Prazosin is best known in psychiatry as an off-label treatment for PTSD nightmares, it suppresses noradrenergic hyperactivity at night and reduces both nightmare frequency and severity in many patients. Originally an antihypertensive; now more often prescribed in mental health than cardiology. First-dose orthostatic hypotension is well-known, start at 1 mg HS and titrate slowly. | ||
| indications = | | indications = | ||
| dosing = | | dosing = | ||