LSD: Difference between revisions
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MDElliottMD (talk | contribs) LSD: correct origin category from Category:Pharma to Category:Pharmaceutical, the canonical origin tag the skin resolver matches (it keys on the literal string Pharmaceutical) |
MDElliottMD (talk | contribs) LSD: add a Pharmacodynamics paragraph on real-world non-clinical dose magnitudes and dose-per-unit uncertainty, sourced from the Erowid LSD Vault (erowid-claude contribution, rendered as descriptive pharmacology per Mark's content-boundary ruling) |
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The compound is unusually potent: threshold psychedelic effects in humans are produced by doses of approximately 20 micrograms, and full psychedelic doses are 100 to 200 micrograms orally. Onset is typically 30 to 60 minutes; the experience reaches plateau at two to three hours and is essentially complete by eight to twelve hours, with residual effects in some subjects extending beyond. The unusually long duration relative to other 5-HT2A agonists is thought to reflect slow dissociation kinetics at the receptor. | The compound is unusually potent: threshold psychedelic effects in humans are produced by doses of approximately 20 micrograms, and full psychedelic doses are 100 to 200 micrograms orally. Onset is typically 30 to 60 minutes; the experience reaches plateau at two to three hours and is essentially complete by eight to twelve hours, with residual effects in some subjects extending beyond. The unusually long duration relative to other 5-HT2A agonists is thought to reflect slow dissociation kinetics at the receptor. | ||
Doses used outside the controlled-trial setting are not standardized. Harm-reduction documentation such as the Erowid LSD Vault records non-clinical oral use extending well above the 100 to 200 micrograms typical of supervised research, into the range of several hundred micrograms.<ref name="erowid-lsd-dose">Erowid. LSD Dosage. Erowid LSD Vault, 1997, last modified 20 February 2017. https://www.erowid.org/chemicals/lsd/lsd_dose.shtml (accessed 20 May 2026).</ref> Because LSD is active at microgram quantities, the amount contained in any non-pharmaceutical unit is inherently uncertain, a point of practical relevance when a clinician is assessing a patient's reported exposure. | |||
| interactions = <pharmaInteractions/> | | interactions = <pharmaInteractions/> | ||
| seealso = [[DMT]], [[Psilocybin]] | | seealso = [[DMT]], [[Psilocybin]] | ||