Fluoxetine: Difference between revisions
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MDElliottMD (talk | contribs) Internal-linking pass per new rule: link diphenhydramine, CYP2D6/CYP3A4 enzyme pages, venlafaxine, duloxetine, and the infobox class categories |
MDElliottMD (talk | contribs) Repoint CYP2D6/CYP3A4 links to the new Enzyme: namespace |
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| pk_absorption = 70–90%<ref name="statpearls">S3</ref> oral bioavailability. | | pk_absorption = 70–90%<ref name="statpearls">S3</ref> oral bioavailability. | ||
| pk_distribution = Fluoxetine has plasma protein binding of approximately 94.5%, bound to albumin and alpha-1 glycoprotein. Fluoxetine readily crosses the blood–brain barrier, with a brain-to-plasma ratio of 2.6:1 in humans. The volume of distribution (Vd) of fluoxetine and its metabolite ranges between 20 to 42 L/kg. Some studies report that fluoxetine has the maximum volume of distribution (Vd) of any SSRI (between 14 and 100 L/kg).<ref name="statpearls"/> | | pk_distribution = Fluoxetine has plasma protein binding of approximately 94.5%, bound to albumin and alpha-1 glycoprotein. Fluoxetine readily crosses the blood–brain barrier, with a brain-to-plasma ratio of 2.6:1 in humans. The volume of distribution (Vd) of fluoxetine and its metabolite ranges between 20 to 42 L/kg. Some studies report that fluoxetine has the maximum volume of distribution (Vd) of any SSRI (between 14 and 100 L/kg).<ref name="statpearls"/> | ||
| pk_metabolism = Fluoxetine's active metabolite is norfluoxetine, produced when the cytochrome P450 enzyme ([[ | | pk_metabolism = Fluoxetine's active metabolite is norfluoxetine, produced when the cytochrome P450 enzyme ([[Enzyme:CYP2D6|CYP2D6]]) acts on it. Prescribers must remember that fluoxetine has several med-med interactions due to its metabolism through the CYP2D6 isoenzyme. Additionally, norfluoxetine can have an inhibitory effect on [[Enzyme:CYP3A4|CYP3A4]]. Fluoxetine has a half-life of 2 to 4 days, and its active metabolite norfluoxetine has a half-life of 7 to 9 days. Approximately 7% of individuals definitively exhibit poor metabolism of fluoxetine due to reduced activity of CYP2D6.<ref name="statpearls"/> | ||
| pk_elimination = | | pk_elimination = | ||
| pharmacodynamics = | | pharmacodynamics = | ||