Sodium Bicarbonate: Difference between revisions
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| pregnancy = Routine antacid and acidosis correction acceptable | | pregnancy = Routine antacid and acidosis correction acceptable | ||
| legal = [[USLegal:Prescription only|Rx-only]] for IV formulations; OTC for oral | | legal = [[USLegal:Prescription only|Rx-only]] for IV formulations; OTC for oral | ||
| mechanism = <vote slug="nahco3-mech-claim">Sodium bicarbonate raises serum pH directly via the carbonic acid / bicarbonate buffer system; in TCA overdose its benefit is partly pH-driven (reducing free | | mechanism = <vote slug="nahco3-mech-claim">Sodium bicarbonate raises serum pH directly via the carbonic acid / bicarbonate buffer system; in TCA overdose its benefit is partly pH-driven (reducing the free unbound fraction) and partly sodium-driven (overcoming TCA sodium-channel blockade), which is why hypertonic 8.4% is preferred over isotonic.</vote> Bicarbonate is not benign: high-volume use produces hypernatremia, metabolic alkalosis, hypokalemia, and (in arrest) paradoxical intracellular acidosis<ref name="nahco3-label" />. | ||
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== References == | == References == | ||
<references /> | <references /> | ||